LongevityMap Gene

Gene details

HGNC symbol: MTOR
Aliases: SKS; FRAP; FRAP1; FRAP2; RAFT1; RAPT1
Common name: mechanistic target of rapamycin
Description: The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008]
Cytogenetic Location: 1p36.22
UCSC Genome Browser: View 1p36.22 on the UCSC genome browser
OMIM: 601231
Ensembl: ENSG00000198793
UniProt/Swiss-Prot: MTOR_HUMAN
Entrez Gene: 2475
UniGene: 338207
1000 Genomes: 1000 Genomes

Homologs in model organisms

Danio rerio: mtor
Drosophila melanogaster: Tor
Mus musculus: Mtor
Rattus norvegicus: Mtor
Saccharomyces cerevisiae: TOR1
Schizosaccharomyces pombe: tor2

In other databases

GenAge model organism genes

A homolog of this gene for Drosophila melanogaster is present as Tor
A homolog of this gene for Saccharomyces cerevisiae is present as TOR1
A homolog of this gene for Mus musculus is present as Mtor

GenAge human genes

This gene is present as MTOR

GenDR gene manipulations

A homolog of this gene for Saccharomyces cerevisiae is present as TOR1

CellAge

This gene is present as MTOR

Studies (3)

Significant/Non-significant: 1/2

Study 1

Longevity Association

Population

Study Design

1,018 SNPs within a 10-kb window around 40 mTOR signalling genes were studied for differences in variation between 417 unrelated nonagenarian participants and 476 younger controls

Conclusions

As a whole, there was a significant association of genetic variation in the mTOR pathway and familial longevity, though no individual gene was significant after correcting for multiple hypothesis testing

Indentifier

Reference

Study 2

Longevity Association: Non-significant
Population: American of Japanese origin
Study Design: 81 tagSNPs that provided virtually complete coverage of key mTOR genes complex genes MTOR, RPTOR, and RICTOR, as well as RPS6KA1, were tested in 814 males (440 aged 95 years and older, 374 controls) for association with longevity and health span phenotypes.
Conclusions: No association was found between genotypes and longevity or aging-related biologic, clinical or functional phenoypes after mutiple test correction.
Indentifier

Study 3

Longevity Association: Non-significant
Population: Italian (Southern)
Study Design: A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
Conclusions: After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
Indentifier