LongevityMap variant

Entry Details

Longevity Association: Non-significant
Population: Jordanian
Study Design: Polymorphisms were genotyped in 130 elderly subjects (57 females, mean age: 90.01 years) and 135 young control subjects (67 females, mean age: 33.43 years) for longevity association
Conclusions: No significant differences were found in the genotype and allele frequencies of examined SOD2 and MTHFR gene variants between the elderly group and young controls (P > 0.05), nor when each gender was considered separately (P > 0.05). SOD2 -9T/C and MTHFR 677C/T were not associated with longevity in the Jordanian population.

HGNC symbol: SOD2
Aliases: IPOB; IPO-B; MNSOD; MVCD6; Mn-SOD
Common name: superoxide dismutase 2
Description: This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. [provided by RefSeq, Apr 2016]
Other longevity studies of this gene: 21
OMIM: 147460
Ensembl: ENSG00000112096
UniProt/Swiss-Prot: A0A0C4DFU1_HUMAN
Entrez Gene: 6648
UniGene: 487046
HapMap: View on HapMap

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Khabour et al. (2009)