LongevityMap Gene
Gene details
- HGNC symbol
- PARP1
- Aliases
- PARP; PPOL; ADPRT; ARTD1; ADPRT1; PARP-1; ADPRT; 1; pADPRT-1
- Common name
- poly(ADP-ribose) polymerase 1
- Description
- This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 1q42.12
- UCSC Genome Browser
- View 1q42.12 on the UCSC genome browser
- OMIM
- 173870
- Ensembl
- ENSG00000143799
- UniProt/Swiss-Prot
- A0A024R3T8_HUMAN
- Entrez Gene
- 142
- UniGene
- 177766
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- parp-1
- Danio rerio
- parp1
- Drosophila melanogaster
- Parp
- Mus musculus
- Parp1
- Rattus norvegicus
- Parp1
In other databases
- GenAge model organism genes
- GenAge human genes
- This gene is present as PARP1
- CellAge gene expression
- This gene is present as PARP1
Studies (5)
Significant/Non-significant: 0/5
Study 1
- Longevity Association
- Non-significant
- Population
- Italian
- Study Design
- Polymorphic repeats in exon 1 were examined in 196 centenarians (143 females and 53 males) and 358 controls (196 females and 162 male; 10-85 years old)
- Conclusions
- No significant difference in genotypic frequencies was found between centenarians and controls
- Indentifier
- PARP1
- Reference
Study 2
- Longevity Association
- Non-significant
- Population
- French
- Study Design
- 324 centenarians and 324 controls were examined for C402T (exon 2), T1011C (exon7), G1215A (exon 8) and T2444C (exon 17) SNPs
- Conclusions
- No association with longevity or with increased cellular poly(ADP-ribosyl)ation capacity was observed
- Indentifier
- C402T
- Reference
Study 3
- Longevity Association
- Non-significant
- Population
- Caucasians
- Study Design
- Meta-analysis of GWAS in Caucasians from four prospective cohort studies: the Age, Gene/Environment Susceptibility-Reykjavik Study, the Cardiovascular Health Study, the Framingham Heart Study, and the Rotterdam Study participating in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Longevity was defined as survival to age 90 years or older (n = 1,836); the comparison group comprised cohort members who died between the ages of 55 and 80 years (n = 1,955).
- Conclusions
- There were 273 single-nucleotide polymorphism (SNP) associations with p < .0001, but none reached significance after correcting for multiple testing
- Indentifier
- rs3219142
- Reference
Study 4
- Longevity Association
- Non-significant
- Population
- American (Caucasian and African–American), Ashkenazi Jewish
- Study Design
- A panel of 477 tag SNPs across 87 candidate genes was screened in >5000 older participants from the population-based Cardiovascular Health Study (CHS). Then, the significant results were validated in Ashkenazi Jews cohort and Study of Osteoporotic Fractures (SOF) cohort.
- Conclusions
- The minor allele of PARP1 rs1805415 was nominally associated with decreased longevity (P = 0.001) and higher IL-6 concentration. The results were replicated in Ashkenazi Jews cohort (P = 0.04), yet failed in the SOF cohort. A pooled analysis revealed a borderline significant association (P = 0.07). rs1805415 is in strong LD with rs1136410.
- Indentifier
- rs1805415
- Reference
Study 5
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
- Conclusions
- The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
- Indentifier
- rs3219142
- Reference