LongevityMap Gene

Gene details

HGNC symbol: PARP1
Aliases: PARP; PPOL; ADPRT; ARTD1; ADPRT1; PARP-1; ADPRT; 1; pADPRT-1
Common name: poly(ADP-ribose) polymerase 1
Description: This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]
Cytogenetic Location: 1q42.12
UCSC Genome Browser: View 1q42.12 on the UCSC genome browser
OMIM: 173870
Ensembl: ENSG00000143799
UniProt/Swiss-Prot: A0A024R3T8_HUMAN
Entrez Gene: 142
UniGene: 177766
1000 Genomes: 1000 Genomes

Homologs in model organisms

Caenorhabditis elegans: parp-1
Danio rerio: parp1
Drosophila melanogaster: Parp
Mus musculus: Parp1
Rattus norvegicus: Parp1

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Parp1
A homolog of this gene for Caenorhabditis elegans is present as pme-1

GenAge human genes

This gene is present as PARP1

CellAge gene expression

This gene is present as PARP1

Studies (5)

Significant/Non-significant: 0/5

Study 1

Longevity Association

Non-significant

Population

Study Design

Polymorphic repeats in exon 1 were examined in 196 centenarians (143 females and 53 males) and 358 controls (196 females and 162 male; 10-85 years old)

Conclusions

No significant difference in genotypic frequencies was found between centenarians and controls

Indentifier

Reference

Study 2

Longevity Association

Non-significant

Population

Study Design

324 centenarians and 324 controls were examined for C402T (exon 2), T1011C (exon7), G1215A (exon 8) and T2444C (exon 17) SNPs

Conclusions

No association with longevity or with increased cellular poly(ADP-ribosyl)ation capacity was observed

Indentifier

Reference

Study 3

Longevity Association: Non-significant
Population: Caucasians
Study Design: Meta-analysis of GWAS in Caucasians from four prospective cohort studies: the Age, Gene/Environment Susceptibility-Reykjavik Study, the Cardiovascular Health Study, the Framingham Heart Study, and the Rotterdam Study participating in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. Longevity was defined as survival to age 90 years or older (n = 1,836); the comparison group comprised cohort members who died between the ages of 55 and 80 years (n = 1,955).
Conclusions: There were 273 single-nucleotide polymorphism (SNP) associations with p < .0001, but none reached significance after correcting for multiple testing
Indentifier

Study 4

Longevity Association: Non-significant
Population: American (Caucasian and African–American), Ashkenazi Jewish
Study Design: A panel of 477 tag SNPs across 87 candidate genes was screened in >5000 older participants from the population-based Cardiovascular Health Study (CHS). Then, the significant results were validated in Ashkenazi Jews cohort and Study of Osteoporotic Fractures (SOF) cohort.
Conclusions: The minor allele of PARP1 rs1805415 was nominally associated with decreased longevity (P = 0.001) and higher IL-6 concentration. The results were replicated in Ashkenazi Jews cohort (P = 0.04), yet failed in the SOF cohort. A pooled analysis revealed a borderline significant association (P = 0.07). rs1805415 is in strong LD with rs1136410.
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Study 5

Longevity Association: Non-significant
Population: Danish
Study Design: 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
Conclusions: The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
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