- Symbol
- pme-1
- Name
- Protein PME-1
- Organism
- Caenorhabditis elegans (AnAge)
- Observations
- pme-1 mutant worms show a 29% mean lifespan extension, whereas RNAi of pme-1 extends lifespan by 20%. PARP inhibition by either AZD2281 or ABT-888 also extends worm lifespan by up to 23%, and does not further extend the lifespan of pme-1 mutants.
- % change in avg or median lifespan
- Lifespan is up to 29% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- RNA interference and/or mutations
- Longevity Category
- Anti-Longevity
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Parp1
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as PARP1
- LongevityMap
- A homolog of this gene for Homo sapiens is present as PARP1
- CellAge gene expression
- A homolog of this gene for Homo sapiens is present as PARP1
- Danio rerio
- parp1
- Drosophila melanogaster
- Parp
- Homo sapiens
- PARP1
- Mus musculus
- Parp1
- Rattus norvegicus
- Parp1
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (266823)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for pme-1 (Caenorhabditis elegans)