LongevityMap variant
Entry Details
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
- Conclusions
- The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
- Identifier
- rs2509049
- In Other Studies (IDs)
- 273
- Cytogenetic Location
- 11q23.3
- UCSC Genome Browser
- View 11q23.3 on the UCSC genome browser
Gene details
- HGNC symbol
- H2AFX
- Aliases
- H2AX; H2A.X; H2A/X
- Common name
- H2A histone family member X
- Description
- Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Oct 2015]
- Other longevity studies of this gene
- 1
- OMIM
- 601772
- Ensembl
- ENSG00000188486
- UniProt/Swiss-Prot
- H2AX_HUMAN
- Entrez Gene
- 3014
- UniGene
- 477879
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- zgc:195633
- Danio rerio
- zgc:110434
- Danio rerio
- zgc:165551
- Danio rerio
- si:ch73-368j24.15
- Danio rerio
- zgc:101846
- Danio rerio
- zgc:165551
- Danio rerio
- h2afx
- Danio rerio
- si:ch1073-159d7.9
- Danio rerio
- zgc:110434
- Danio rerio
- zgc:195633
- Drosophila melanogaster
- His2A:CG33865
- Drosophila melanogaster
- His2A:CG33826
- Drosophila melanogaster
- His2A:CG33865
- Drosophila melanogaster
- His2A:CG33847
- Drosophila melanogaster
- His2A:CG33847
- Drosophila melanogaster
- His2A:CG33847
- Drosophila melanogaster
- His2A:CG33826
- Drosophila melanogaster
- His2A:CG33865
- Drosophila melanogaster
- His2A:CG33826
- Drosophila melanogaster
- His2A:CG33865
- Drosophila melanogaster
- His2A:CG33826
- Drosophila melanogaster
- His2A:CG33826
- Drosophila melanogaster
- His2A:CG33865
- Drosophila melanogaster
- His2A:CG33826
- Drosophila melanogaster
- His2A:CG33847
- Drosophila melanogaster
- His2A:CG33865
- Drosophila melanogaster
- His2A:CG33847
- Drosophila melanogaster
- His2A:CG33847
- Drosophila melanogaster
- His2A:CG33865
- Drosophila melanogaster
- His2A:CG33826
- Drosophila melanogaster
- His2A:CG33847
- Drosophila melanogaster
- His2A:CG33865
- Drosophila melanogaster
- His2A:CG33847
- Drosophila melanogaster
- His2A:CG33847
- Drosophila melanogaster
- His2A:CG33865
- Drosophila melanogaster
- His2A:CG33847
- Drosophila melanogaster
- His2A:CG33826
- Drosophila melanogaster
- His2A:CG33847
- Drosophila melanogaster
- His2A:CG33826
- Drosophila melanogaster
- His2A:CG33865
- Drosophila melanogaster
- His2A:CG33826
- Drosophila melanogaster
- His2A:CG33865
- Drosophila melanogaster
- His2A:CG33847
- Drosophila melanogaster
- His2A:CG33826
- Drosophila melanogaster
- His2A:CG33865
- Drosophila melanogaster
- His2A:CG33826
- Drosophila melanogaster
- His2A:CG33847
- Drosophila melanogaster
- His2A:CG33826
- Drosophila melanogaster
- His2A:CG33847
- Drosophila melanogaster
- His2A:CG33847
- Drosophila melanogaster
- His2A:CG33865
- Drosophila melanogaster
- His2A:CG33865
- Drosophila melanogaster
- His2A:CG33826
- Drosophila melanogaster
- His2A:CG33865
- Drosophila melanogaster
- His2A:CG33865
- Drosophila melanogaster
- His2A:CG33826
- Drosophila melanogaster
- His2A:CG33847
- Drosophila melanogaster
- His2A:CG33826
- Drosophila melanogaster
- His2A:CG33847
- Drosophila melanogaster
- His2A:CG33826
- Drosophila melanogaster
- His2A:CG33865
- Mus musculus
- H2afx
- Rattus norvegicus
- H2afx
- Saccharomyces cerevisiae
- HTA1