LongevityMap Gene

Gene details

HGNC symbol: H2AFX
Aliases: H2AX; H2A.X; H2A/X
Common name: H2A histone family member X
Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Oct 2015]
Cytogenetic Location: 11q23.3
UCSC Genome Browser: View 11q23.3 on the UCSC genome browser
OMIM: 601772
Ensembl: ENSG00000188486
UniProt/Swiss-Prot: H2AX_HUMAN
Entrez Gene: 3014
UniGene: 477879
1000 Genomes: 1000 Genomes

Homologs in model organisms

Danio rerio: zgc:195633
Danio rerio: zgc:110434
Danio rerio: zgc:165551
Danio rerio: si:ch73-368j24.15
Danio rerio: zgc:101846
Danio rerio: zgc:165551
Danio rerio: h2afx
Danio rerio: si:ch1073-159d7.9
Danio rerio: zgc:110434
Danio rerio: zgc:195633
Drosophila melanogaster: His2A:CG33865
Drosophila melanogaster: His2A:CG33826
Drosophila melanogaster: His2A:CG33865
Drosophila melanogaster: His2A:CG33847
Drosophila melanogaster: His2A:CG33847
Drosophila melanogaster: His2A:CG33847
Drosophila melanogaster: His2A:CG33826
Drosophila melanogaster: His2A:CG33865
Drosophila melanogaster: His2A:CG33826
Drosophila melanogaster: His2A:CG33865
Drosophila melanogaster: His2A:CG33826
Drosophila melanogaster: His2A:CG33826
Drosophila melanogaster: His2A:CG33865
Drosophila melanogaster: His2A:CG33826
Drosophila melanogaster: His2A:CG33847
Drosophila melanogaster: His2A:CG33865
Drosophila melanogaster: His2A:CG33847
Drosophila melanogaster: His2A:CG33847
Drosophila melanogaster: His2A:CG33865
Drosophila melanogaster: His2A:CG33826
Drosophila melanogaster: His2A:CG33847
Drosophila melanogaster: His2A:CG33865
Drosophila melanogaster: His2A:CG33847
Drosophila melanogaster: His2A:CG33847
Drosophila melanogaster: His2A:CG33865
Drosophila melanogaster: His2A:CG33847
Drosophila melanogaster: His2A:CG33826
Drosophila melanogaster: His2A:CG33847
Drosophila melanogaster: His2A:CG33826
Drosophila melanogaster: His2A:CG33865
Drosophila melanogaster: His2A:CG33826
Drosophila melanogaster: His2A:CG33865
Drosophila melanogaster: His2A:CG33847
Drosophila melanogaster: His2A:CG33826
Drosophila melanogaster: His2A:CG33865
Drosophila melanogaster: His2A:CG33826
Drosophila melanogaster: His2A:CG33847
Drosophila melanogaster: His2A:CG33826
Drosophila melanogaster: His2A:CG33847
Drosophila melanogaster: His2A:CG33847
Drosophila melanogaster: His2A:CG33865
Drosophila melanogaster: His2A:CG33865
Drosophila melanogaster: His2A:CG33826
Drosophila melanogaster: His2A:CG33865
Drosophila melanogaster: His2A:CG33865
Drosophila melanogaster: His2A:CG33826
Drosophila melanogaster: His2A:CG33847
Drosophila melanogaster: His2A:CG33826
Drosophila melanogaster: His2A:CG33847
Drosophila melanogaster: His2A:CG33826
Drosophila melanogaster: His2A:CG33865
Mus musculus: H2afx
Rattus norvegicus: H2afx
Saccharomyces cerevisiae: HTA1

In other databases

GenAge human genes

This gene is present as H2AFX

CellAge gene expression

This gene is present as H2AFX

Studies (2)

Significant/Non-significant: 1/1

Study 1

Longevity Association: Significant
Population: Danish
Study Design: Alleles in candidate pathways (GH/IGF1 signaling, DNA damage signaling and repair and pro/antioxidants) were investigated for association with longevity in 1089 oldest-old (age 92-93) and 736 middle-aged Danes
Conclusions: Six SNPs (in TNXRD1, XDH, GHRL, MLH1, H2AFX, XRCC5) were associated with mortality in late life after correction for multiple hypothesis testing. No replications were observed in German and Dutch populations.
Indentifier

Study 2

Longevity Association: Non-significant
Population: Danish
Study Design: 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
Conclusions: The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
Indentifier