GenAge entry for SNCG (Homo sapiens)

Gene name (HAGRID: 140)

HGNC symbol: SNCG
Aliases: BCSG1; SR; persyn
Common name: synuclein, gamma (breast cancer-specific protein 1)

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description: SNCG is a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. SNCG also appears to regulate BUB1B [1702]. While SNCG has been linked to cancer and CNS development [1083], its role, if any, in human ageing is unknown.

Cytogenetic information

Cytogenetic band: 10q23.2-q2
Location: 86,958,531 bp to 86,963,260 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0007268; chemical synaptic transmission
GO:0008344; adult locomotory behavior
GO:0009306; protein secretion
GO:0014059; regulation of dopamine secretion
GO:0046928; regulation of neurotransmitter secretion
GO:0050808; synapse organization

Cellular component:

GO:0005737; cytoplasm
GO:0005815; microtubule organizing center
GO:0005819; spindle
GO:0030424; axon
GO:0043025; neuronal cell body
GO:0048471; perinuclear region of cytoplasm
GO:0070062; extracellular exosome

Function:

GO:0005515; protein binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TERF1, MAPK8, MAPK3, BUB1B
STRING interaction network

Retrieve sequences for SNCG

ORF: ORF
CDS: CDS

Homologs in model organisms

Mus musculus: Sncg
Rattus norvegicus: Sncg

In other databases

GenAge microarray genes

This gene is present as SNCG