GenAge entry for TPP2 (Homo sapiens)
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Gene name (HAGRID: 273)
- HGNC symbol
- TPP2
- Aliases
- Common name
- tripeptidyl peptidase II
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
- Description
In human embryonic kidney cells overexpression of TPP2 induces accelerated growth and resistance to apoptosis, correlated with the appearance of multiple chromosomal aberrations, numerical and structural centrosome abnormalities, and multipolar cell divisions, suggesting a role in the regulation of centrosome homeostasis and mitotic fidelity [2185].
Knockout in mice resulted in viable animals which are almost indistinguishable from their wild type littermates when young. After the age of 1 year mutant mice show an increased mortality and multiple signs of premature ageing. They exhibt an aged appearance, disheveled fur, large bald areas, reduced body mass, and loss of vigor. Mice also show symptoms characteristic of immunohematopoietic senescence, including accelerated thymic involution, lymphopenia, impaired proliferative T cell responses, extramedullary hematopoiesis, and inflammation. Premature cellular senescence in fibroblasts, coinciding with the upregulation of TP53 and the dysregulation of NFKB1 was also observed [2184].
Cytogenetic information
- Cytogenetic band
- 13q32-q33
- Location
- 102,596,936 bp to 102,679,173 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000209; protein polyubiquitination
GO:0006508; proteolysis
Cellular component: GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005829; cytosol
Function: GO:0004175; endopeptidase activity
GO:0004177; aminopeptidase activity
GO:0004252; serine-type endopeptidase activity
GO:0005515; protein binding
GO:0008240; tripeptidyl-peptidase activity
GO:0042277; peptide binding
Protein interactions and network
Retrieve sequences for TPP2
Homologs in model organisms
- Caenorhabditis elegans
- tpp-2
- Danio rerio
- TPP2
- Drosophila melanogaster
- TppII
- Mus musculus
- Tpp2
- Rattus norvegicus
- Tpp2
- Schizosaccharomyces pombe
- tpp2
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Tpp2
Selected references
External links
- EPD
- ORF Accession
- NM_003291
- CDS Accession
- NP_003282
- OMIM
- 190470
- HPRD
- 01834
- Ensembl
- TPP2
- UniProt/Swiss-Prot
- TPP2_HUMAN
- GeneCards
- TPP2
- Entrez Gene
- 7174
- GenAtlas
- TPP2
- Internet
- Search Google