GenAge entry for POLB (Homo sapiens)
Gene name (HAGRID: 236)
- HGNC symbol
- POLB
- Aliases
- Common name
- polymerase (DNA directed), beta
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
- Description
POLB is involved in DNA maintenance, replication, and recombination. It appears to play a role in DNA repair and it interacts with WRN [1520]. In mice, POLB haploinsufficiency increases cancer risk with age. While lifespan is not significantly altered, haploinsufficient mice may exhibit an increase in age-related mortality [1815]. POLB's role, if any, in human ageing remains to be determined.
Cytogenetic information
- Cytogenetic band
- 8p11.2
- Location
- 42,338,455 bp to 42,371,813 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0006261; DNA-dependent DNA replication
GO:0006281; DNA repair
GO:0006284; base-excision repair
GO:0006286; base-excision repair, base-free sugar-phosphate removal
GO:0006287; base-excision repair, gap-filling
GO:0006288; base-excision repair, DNA ligation
GO:0006290; pyrimidine dimer repair
GO:0006297; nucleotide-excision repair, DNA gap filling
GO:0006954; inflammatory response
GO:0006974; cellular response to DNA damage stimulus
GO:0007435; salivary gland morphogenesis
And 13 more GO terms Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005874; microtubule
GO:0005876; spindle microtubule
GO:0043234; protein complex
Function: GO:0003684; damaged DNA binding
GO:0003887; DNA-directed DNA polymerase activity
GO:0003906; DNA-(apurinic or apyrimidinic site) lyase activity
GO:0005515; protein binding
GO:0008017; microtubule binding
GO:0016829; lyase activity
GO:0019899; enzyme binding
GO:0046872; metal ion binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- WRN, PARP1, EP300, APTX, PCNA, APEX1, STUB1, TPP2
- STRING interaction network
Retrieve sequences for POLB
Homologs in model organisms
In other databases
- LongevityMap
- This gene is present as POLB
Selected references
External links
- EPD
- ORF Accession
- NM_002690
- CDS Accession
- NP_002681
- OMIM
- 174760
- HPRD
- 07517
- Ensembl
- POLB
- UniProt/Swiss-Prot
- DPOLB_HUMAN
- GeneCards
- POLB
- Entrez Gene
- 5423
- GenAtlas
- POLB
- Internet
- Search Google