GenAge entry for RAD52 (Homo sapiens)
Gene name (HAGRID: 147)
- HGNC symbol
- RAD52
- Aliases
- Common name
- RAD52 homolog, DNA repair protein
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a cellular model system
- Description
RAD52 is involved in DNA repair and appears to interact with WRN [727]. It has been reported to be an important player in the cellular senescence of yeast [192]. Its role, if any, in mammalian ageing remains elusive.
Cytogenetic information
- Cytogenetic band
- 12p13-p12.
- Location
- 912,077 bp to 990,053 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0000730; DNA recombinase assembly
GO:0006302; double-strand break repair
GO:0006310; DNA recombination
GO:0006974; cellular response to DNA damage stimulus
GO:0010792; DNA double-strand break processing involved in repair via single-strand annealing
GO:0016925; protein sumoylation
GO:0034599; cellular response to oxidative stress
GO:2000819; regulation of nucleotide-excision repair
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0043234; protein complex
Function: GO:0003677; DNA binding
GO:0005515; protein binding
GO:0042802; identical protein binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- ERCC2, WRN, RPA1, HSP90AA1, RAD51, UBE2I, ERCC3, PRDX1, RAD52, HSPD1, YWHAZ, EEF1A1, HSPA8, SUMO1
- STRING interaction network
Retrieve sequences for RAD52
Homologs in model organisms
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as RAD52
- LongevityMap
- This gene is present as RAD52
Selected references
External links
- EPD
- ORF Accession
- NM_002879
- CDS Accession
- NP_002870
- OMIM
- 600392
- HPRD
- 11855
- Ensembl
- RAD52
- UniProt/Swiss-Prot
- RAD52_HUMAN
- GeneCards
- RAD52
- Entrez Gene
- 5893
- GenAtlas
- RAD52
- Internet
- Search Google