GenAge entry for RAD52 (Homo sapiens)

Gene name (HAGRID: 147)

HGNC symbol
RAD52 
Aliases
 
Common name
RAD52 homolog, DNA repair protein 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a cellular model system
Description

RAD52 is involved in DNA repair and appears to interact with WRN [727]. It has been reported to be an important player in the cellular senescence of yeast [192]. Its role, if any, in mammalian ageing remains elusive.

Cytogenetic information

Cytogenetic band
12p13-p12.
Location
912,077 bp to 990,053 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000730; DNA recombinase assembly
GO:0006302; double-strand break repair
GO:0006310; DNA recombination
GO:0006974; cellular response to DNA damage stimulus
GO:0010792; DNA double-strand break processing involved in repair via single-strand annealing
GO:0016925; protein sumoylation
GO:0034599; cellular response to oxidative stress
GO:2000819; regulation of nucleotide-excision repair
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0043234; protein complex
Function: GO:0003677; DNA binding
GO:0005515; protein binding
GO:0042802; identical protein binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
ERCC2, WRN, RPA1, HSP90AA1, RAD51, UBE2I, ERCC3, PRDX1, RAD52, HSPD1, YWHAZ, EEF1A1, HSPA8, SUMO1
STRING interaction network
Protein-Protein network diagram for RAD52

Retrieve sequences for RAD52

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
rad52
Mus musculus
Rad52
Rattus norvegicus
Rad52
Saccharomyces cerevisiae
RAD52

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as RAD52
LongevityMap
  • This gene is present as RAD52

Selected references

External links

EPD
ORF Accession
NM_002879
CDS Accession
NP_002870
OMIM
600392
HPRD
11855
Ensembl
RAD52
UniProt/Swiss-Prot
RAD52_HUMAN
GeneCards
RAD52
Entrez Gene
5893
GenAtlas
RAD52
Internet
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