GenAge entry for PCMT1 (Homo sapiens)

Gene name (HAGRID: 162)

HGNC symbol: PCMT1
Aliases
Common name: protein-L-isoaspartate (D-aspartate) O-methyltransferase

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description: PCMT1 is involved in the repair and degradation of damaged proteins. Overexpression of a PCMT1 homologue in fruit flies extends lifespan in a temperature-dependent fashion [211]. PCMT1-deficient mice die at about 42 days after birth, though without signs of premature ageing [760]. Although an age-related accumulation of defective proteins has been suggested as a factor in ageing, further research is needed to assess PCMT1's role, if any, in mammalian ageing.

Cytogenetic information

Cytogenetic band: 6q24-q25
Location: 149,749,695 bp to 149,811,421 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0006479; protein methylation
GO:0030091; protein repair
GO:0098609; cell-cell adhesion

Cellular component:

GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0005913; cell-cell adherens junction
GO:0070062; extracellular exosome
GO:1903561; extracellular vesicle

Function:

GO:0004719; protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
GO:0005515; protein binding
GO:0098641; cadherin binding involved in cell-cell adhesion

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, LMNA, TERF1, TERF2, SOD1, APOE, CSNK1E, TP53BP1, MIF, TRAP1
STRING interaction network

Retrieve sequences for PCMT1

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: pcm-1
Danio rerio: pcmt
Drosophila melanogaster: Pcmt
Mus musculus: Pcmt1
Rattus norvegicus: Pcmt1
Schizosaccharomyces pombe: pcm2

In other databases

GenAge model organism genes

A homolog of this gene for Drosophila melanogaster is present as Pcmt
A homolog of this gene for Caenorhabditis elegans is present as pcm-1