GenAge entry for TRAP1 (Homo sapiens)
Gene name (HAGRID: 305)
- HGNC symbol
- TRAP1
- Aliases
- HSP75; HSP90L
- Common name
- TNF receptor-associated protein 1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
- Description
TNFR-associated protein-1 (TRAP1) encodes a mitochondrial chaperone protein that is a member of the HSP90 family, and is thought to protect against oxidative stress and apoptosis. Knockout (-/-) of TRAP1 in mice produces viable mutants, with a reduced incidence of age-associated pathologies, including obesity, inflammatory tissue degeneration, dysplasia, and spontaneous tumour formation [3656].
Cytogenetic information
- Cytogenetic band
- 16p13.3
- Location
- 3,658,037 bp to 3,717,597 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0006950; response to stress
GO:0009386; translational attenuation
GO:0061077; chaperone-mediated protein folding
GO:1901856; negative regulation of cellular respiration
GO:1903427; negative regulation of reactive oxygen species biosynthetic process
GO:1903751; negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
Cellular component: GO:0005654; nucleoplasm
GO:0005739; mitochondrion
GO:0005743; mitochondrial inner membrane
GO:0005758; mitochondrial intermembrane space
GO:0005759; mitochondrial matrix
GO:0005811; lipid particle
GO:0016020; membrane
GO:0070062; extracellular exosome
Function: GO:0005164; tumor necrosis factor receptor binding
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0019901; protein kinase binding
GO:0044822; poly(A) RNA binding
GO:0051082; unfolded protein binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- RB1, SOD1, APP, PCMT1, EEF1A1, H2AFX
- STRING interaction network
Retrieve sequences for TRAP1
Homologs in model organisms
- Caenorhabditis elegans
- hsp-75
- Danio rerio
- trap1
- Drosophila melanogaster
- Trap1
- Mus musculus
- Trap1
- Rattus norvegicus
- Trap1
- Saccharomyces cerevisiae
- HSP82
- Saccharomyces cerevisiae
- HSC82
In other databases
- CellAge gene expression
- This gene is present as TRAP1