GenAge entry for NFE2L1 (Homo sapiens)

Gene name (HAGRID: 307)

HGNC symbol: NFE2L1
Aliases: NRF1; LCR-F1; FLJ00380; TCF11
Common name: nuclear factor, erythroid 2-like 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description: The Nuclear Factor, Erythroid 2-Like 1 (NFE2L1), is involved in globin gene expression in erythrocytes. Overexpressing SKN-1, one of its ortholog genes, in worms has been reported to mildly extend lifespan (by 5-20%) [2497]. Contrastly, RNA interference in SKN-1 prevents the life-extension effects of caloric restriction [2360] and it was shown that SKN-1 is involved in the insulin/IGF-1 signaling, being necessary for the DAF-16/DAF-2 lifespan extension pathway [3650].

Cytogenetic information

Cytogenetic band: 17q21.3
Location: 48,048,324 bp to 48,061,545 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0006357; regulation of transcription from RNA polymerase II promoter
GO:0006366; transcription from RNA polymerase II promoter
GO:0006783; heme biosynthetic process
GO:0006954; inflammatory response
GO:0009653; anatomical structure morphogenesis
GO:0030218; erythrocyte differentiation
GO:0034599; cellular response to oxidative stress
GO:0045893; positive regulation of transcription, DNA-templated
GO:0045944; positive regulation of transcription from RNA polymerase II promoter

Cellular component:

GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005789; endoplasmic reticulum membrane
GO:0016021; integral component of membrane

Function:

GO:0000976; transcription regulatory region sequence-specific DNA binding
GO:0000980; RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001190; transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0001205; transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003712; transcription cofactor activity
GO:0005515; protein binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: GSK3B, JUN, NFE2L1
STRING interaction network

Retrieve sequences for NFE2L1

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: nfe2l1a
Drosophila melanogaster: cnc
Mus musculus: Nfe2l1
Rattus norvegicus: Nfe2l1