GenAge entry for MSRA (Homo sapiens)
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Gene name (HAGRID: 127)
- HGNC symbol
- MSRA
- Aliases
- Common name
- methionine sulfoxide reductase A
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
- Description
MSRA repairs damage resulting from oxidative stress. Results from invertebrates suggest a role for MSRA in ageing. Overexpression of a MSRA homologue in fruit flies extends lifespan [42]. Disruption of MSRA in mice decreases longevity and, albeit not proven, might accelerate ageing [43]. Elevated expression of human MSRA in transgenic mice reduces the rate of age-related death in female mice when targeted to the cytosol, and improves insulin sensitivity when targeted to the mitochondria. However, neither intervention extends lifespan [4486]. In humans, MSRA has been associated with age-related diseases, such as Alzheimer's disease [978]. Therefore, MSRA could be involved in human ageing.
Cytogenetic information
- Cytogenetic band
- 8p23.1
- Location
- 10,054,269 bp to 10,428,891 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0006464; cellular protein modification process
GO:0006555; methionine metabolic process
GO:0006979; response to oxidative stress
GO:0030091; protein repair
GO:0055114; oxidation-reduction process
Cellular component: GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol
GO:0015629; actin cytoskeleton
GO:0016020; membrane
GO:0070062; extracellular exosome
Function: GO:0008113; peptide-methionine (S)-S-oxide reductase activity
Protein interactions and network
No interactions in records.
Retrieve sequences for MSRA
Homologs in model organisms
- Caenorhabditis elegans
- msra-1
- Danio rerio
- msra
- Drosophila melanogaster
- Eip71CD
- Mus musculus
- Msra
- Rattus norvegicus
- Msra
- Saccharomyces cerevisiae
- MXR1
- Schizosaccharomyces pombe
- mxr1
In other databases
- GenAge model organism genes
Selected references
External links
- EPD
- ORF Accession
- NM_012331
- CDS Accession
- NP_036463
- OMIM
- 601250
- HPRD
- 03152
- Ensembl
- MSRA
- UniProt/Swiss-Prot
- MSRA_HUMAN
- GeneCards
- MSRA
- Entrez Gene
- 4482
- GenAtlas
- MSRA
- Internet
- Search Google