GenAge entry for HOXC4 (Homo sapiens)

Gene name (HAGRID: 214)

HGNC symbol: HOXC4
Aliases: HOX3; HOX3E
Common name: homeobox C4

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description: HOXC4 is a member of the homeobox family, also called HOX, crucial in morphogenesis and development [1024]. The expression of many HOX genes, including HOXC4, declines with age, even prior to adulthood [1020]. HOXC4 also interacts with XRCC6 and PRKDC [1017]. An association of HOX genes with longevity has been proposed [1022], though there is no direct evidence linking HOXC4 to human ageing.

Cytogenetic information

Cytogenetic band: 12q13.3
Location: 54,053,877 bp to 54,056,030 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0006351; transcription, DNA-templated
GO:0006355; regulation of transcription, DNA-templated
GO:0009952; anterior/posterior pattern specification
GO:0048562; embryonic organ morphogenesis
GO:0051216; cartilage development

Cellular component:

GO:0005634; nucleus

Function:

GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0005515; protein binding
GO:0043565; sequence-specific DNA binding
GO:0071837; HMG box domain binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: HTT, XRCC5, XRCC6, APP
STRING interaction network

Retrieve sequences for HOXC4

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: lin-39
Danio rerio: hoxc4a
Drosophila melanogaster: Dfd
Mus musculus: Hoxc4
Rattus norvegicus: Hoxc4