GenAge entry for EEF1E1 (Homo sapiens)
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Gene name (HAGRID: 266)
- HGNC symbol
- EEF1E1
- Aliases
- AIMP3; P18
- Common name
- eukaryotic translation elongation factor 1 epsilon 1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
- Description
The eukaryotic translation elongation factor 1 epsilon 1 (EEF1E1), also known as p18, is a well-known tumor suppressor, which plays a role in the ATM/ATR-mediated p53 (TP53) activation [2155].
Knockout mice result in early embryonic death (homozygous) or are born alive but show highly increased susceptibility to various cancers (heterozygous). On the other hand, transgenic mice overexpressing EEF1E1 constitutively have an imbalance in the protein levels of lamin A (LMNA) isoforms, and thus a significantly shorter mean lifespan and a phenotype characteristic to mouse progeroid models [2156].
The expression of p18 is downregulated in gastric and colorectal cancers [2157].
Cytogenetic information
- Cytogenetic band
- 6p24.3
- Location
- 8,073,360 bp to 8,102,595 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0006414; translational elongation
GO:0006418; tRNA aminoacylation for protein translation
GO:0006749; glutathione metabolic process
GO:0008285; negative regulation of cell proliferation
GO:0043065; positive regulation of apoptotic process
GO:0043517; positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:2000774; positive regulation of cellular senescence
Cellular component: GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0070062; extracellular exosome
Function: GO:0003746; translation elongation factor activity
GO:0004364; glutathione transferase activity
GO:0005515; protein binding
Protein interactions and network
No interactions in records.
Retrieve sequences for EEF1E1
Homologs in model organisms
In other databases
Selected references
External links
- EPD
- ORF Accession
- NM_001135650
- CDS Accession
- NP_001129122
- OMIM
- 609206
- HPRD
- 10931
- Ensembl
- EEF1E1
- UniProt/Swiss-Prot
- MCA3_HUMAN
- GeneCards
- EEF1E1
- Entrez Gene
- 9521
- GenAtlas
- EEF1E1
- Internet
- Search Google