Cell Senescence Entries for EEF1E1

Cell Types
Umbilical cord blood-derived mesenchymal stem
Cell Lines
HUCB
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Lee et al. (2015) miR-543 and miR-590-3p regulate human mesenchymal stem cell aging via direct targeting of AIMP3/p18. Age (Dordr) 36(6)9724 (PubMed)

EEF1E1 Gene Information

HGNC symbol
EEF1E1 
Aliases
AIMP3; P18 
Common name
eukaryotic translation elongation factor 1 epsilon 1 
Entrez Id
9521
Description
This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2010].

EEF1E1 Ontologies

Gene Ontology
Process: GO:6412; translation
GO:43065; positive regulation of apoptotic process
GO:8285; negative regulation of cell population proliferation
GO:43517; positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:2000774; positive regulation of cellular senescence
GO:1990830; cellular response to leukemia inhibitory factor
GO:2001235; positive regulation of apoptotic signaling pathway
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:5829; cytosol
GO:17101; aminoacyl-tRNA synthetase multienzyme complex
GO:16020; membrane
GO:16021; integral component of membrane
Function: GO:5515; protein binding
Show all GO terms

Homologs of EEF1E1 in Model Organisms

Danio rerio
eef1e1
Drosophila melanogaster
CG30185

In other databases

GenAge human genes
  • This gene is present as EEF1E1
CellAge gene expression
  • This gene is present as EEF1E1

External links

OMIM
609206
Ensembl
ENSG00000124802
Entrez Gene
9521
UniGene
745033
1000 Genomes
1000 Genomes
HPRD
GenAtlas
EEF1E1
GeneCards
EEF1E1