GenAge entry for HELLS (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 101)

HGNC symbol: HELLS
Aliases: PASG; SMARCA6; LSH; Nbla10143
Common name: helicase, lymphoid-specific

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description: HELLS is a transcriptional regulator acting on chromatin and maybe affecting cellular proliferation. It has been linked to leukaemia [1047]. About 60% of HELLS-null mice die shortly after birth. Survivors do not commonly live more than a month but exhibit growth retardation and signs of premature ageing [1045]. Whether HELLS impacts on human ageing is unknown.

Cytogenetic information

Cytogenetic band: 10q24.2
Location: 94,545,767 bp to 94,602,099 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0006346; methylation-dependent chromatin silencing
GO:0006351; transcription, DNA-templated
GO:0007067; mitotic nuclear division
GO:0007275; multicellular organism development
GO:0010216; maintenance of DNA methylation
GO:0031508; pericentric heterochromatin assembly
GO:0046651; lymphocyte proliferation
GO:0051301; cell division

Cellular component:

GO:0000775; chromosome, centromeric region
GO:0005634; nucleus
GO:0005721; pericentric heterochromatin

Function:

GO:0004386; helicase activity
GO:0005515; protein binding
GO:0005524; ATP binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: MYC, EGFR, VCP, APP, HDAC1, HDAC2
STRING interaction network

Retrieve sequences for HELLS

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: hells
Mus musculus: Hells
Rattus norvegicus: Hells
Rattus norvegicus: LOC100911660
Rattus norvegicus: Hells
Rattus norvegicus: LOC100911660
Saccharomyces cerevisiae: IRC5

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Hells

CellAge

This gene is present as HELLS

CellAge gene expression

This gene is present as HELLS