GenAge entry for ARHGAP1 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 249)

HGNC symbol: ARHGAP1
Aliases: RhoGAP; p50rhoGAP; CDC42GAP; Cdc42GAP
Common name: Rho GTPase activating protein 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description: ARHGAP1 a GTPase activator of several proteins. In effect, it acts as a negative regulator of CDC42. Gene targeting of ARHGAP1 in mice results in a short lifespan of about 12 months and the development of multiple premature ageing-like phenotypes, suggesting that this gene may play a role in mammalian ageing [1840].

Cytogenetic information

Cytogenetic band: 11p11.2
Location: 46,677,075 bp to 46,700,665 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0007264; small GTPase mediated signal transduction
GO:0007266; Rho protein signal transduction
GO:0009967; positive regulation of signal transduction
GO:0043547; positive regulation of GTPase activity
GO:0051056; regulation of small GTPase mediated signal transduction
GO:0098609; cell-cell adhesion

Cellular component:

GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0005913; cell-cell adherens junction
GO:0048471; perinuclear region of cytoplasm
GO:0070062; extracellular exosome

Function:

GO:0005070; SH3/SH2 adaptor activity
GO:0005096; GTPase activator activity
GO:0005515; protein binding
GO:0017124; SH3 domain binding
GO:0098641; cadherin binding involved in cell-cell adhesion

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: EGFR, PIK3R1, CHEK2, ARHGAP1, CDC42
STRING interaction network

Retrieve sequences for ARHGAP1

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: rga-1
Danio rerio: arhgap1
Drosophila melanogaster: RhoGAP68F
Mus musculus: Arhgap1
Rattus norvegicus: Arhgap1

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Arhgap1