- Symbol
- Arhgap1
- Aliases
- C76222; Cdc42GAP; p50rhoGAP; RP23-12H6.2; B230365D05Ri
- Name
- Rho GTPase activating protein 1
- Organism
- Mus musculus (AnAge)
- Known functions and activities
- Regulation of actin cytoskeleton organization, polarity, and growth
- Observations
- Most knockout mice were weak and died during the neonatal period. Animals that survived had a shorter lifespan (median lifespan was 12 months) and showed premature ageing-like phenotypes, including a reduction in body mass, a loss of subdermal adipose tissue, lordokyphosis, and osteoporosis.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Knockout
- Longevity Category
- Pro-Longevity
- Primary reference
-
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as ARHGAP1
- Caenorhabditis elegans
- rga-1
- Danio rerio
- arhgap1
- Drosophila melanogaster
- RhoGAP68F
- Homo sapiens
- ARHGAP1
- Rattus norvegicus
- Arhgap1
- Mouse Genome Informatics
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (228359)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Arhgap1 (Mus musculus)