GenAge entry for MSRA (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 127)

HGNC symbol: MSRA
Aliases
Common name: methionine sulfoxide reductase A

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description: MSRA repairs damage resulting from oxidative stress. Results from invertebrates suggest a role for MSRA in ageing. Overexpression of a MSRA homologue in fruit flies extends lifespan [42]. Disruption of MSRA in mice decreases longevity and, albeit not proven, might accelerate ageing [43]. Elevated expression of human MSRA in transgenic mice reduces the rate of age-related death in female mice when targeted to the cytosol, and improves insulin sensitivity when targeted to the mitochondria. However, neither intervention extends lifespan [4486]. In humans, MSRA has been associated with age-related diseases, such as Alzheimer's disease [978]. Therefore, MSRA could be involved in human ageing.

Cytogenetic information

Cytogenetic band: 8p23.1
Location: 10,054,269 bp to 10,428,891 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0006464; cellular protein modification process
GO:0006555; methionine metabolic process
GO:0006979; response to oxidative stress
GO:0030091; protein repair
GO:0055114; oxidation-reduction process

Cellular component:

GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol
GO:0015629; actin cytoskeleton
GO:0016020; membrane
GO:0070062; extracellular exosome

Function:

GO:0008113; peptide-methionine (S)-S-oxide reductase activity

Show all GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for MSRA

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: msra-1
Danio rerio: msra
Drosophila melanogaster: Eip71CD
Mus musculus: Msra
Rattus norvegicus: Msra
Saccharomyces cerevisiae: MXR1
Schizosaccharomyces pombe: mxr1

In other databases

GenAge model organism genes

A homolog of this gene for Drosophila melanogaster is present as Eip71CD
A homolog of this gene for Mus musculus is present as Msra
A homolog of this gene for Saccharomyces cerevisiae is present as MXR1