GenAge entry for HIC1 (Homo sapiens)

Gene name (HAGRID: 253)

HGNC symbol: HIC1
Aliases: ZBTB29; ZNF901
Common name: hypermethylated in cancer 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description: HIC1 is a transcriptional repressor. It suppresses age-dependent development of cancer in mice together with TP53. HIC1 also forms a complex with SIRT1 that represses SIRT1 expression. Ageing increases promoter hypermethylation and epigenetic silencing of HIC1 [1582]. Therefore, HIC1 might play some role in ageing, though further studies are warranted.

Cytogenetic information

Cytogenetic band: 17p13.3
Location: 2,055,099 bp to 2,059,687 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0006351; transcription, DNA-templated
GO:0006355; regulation of transcription, DNA-templated
GO:0007275; multicellular organism development
GO:0008630; intrinsic apoptotic signaling pathway in response to DNA damage
GO:0016055; Wnt signaling pathway
GO:0030178; negative regulation of Wnt signaling pathway
GO:0043517; positive regulation of DNA damage response, signal transduction by p53 class mediator

Cellular component:

GO:0000785; chromatin
GO:0005654; nucleoplasm
GO:0005737; cytoplasm

Function:

GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0005515; protein binding
GO:0042826; histone deacetylase binding
GO:0043565; sequence-specific DNA binding
GO:0046872; metal ion binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: STAT3, UBE2I, SIRT1, SP1, HIC1
STRING interaction network

GenAge entry for HIC1 (Homo sapiens)

Gene name (HAGRID: 253)

Potential relevance to the human ageing process

Cytogenetic information

Protein information

Protein interactions and network

Retrieve sequences for HIC1

Homologs in model organisms

Selected references

External links