GenAge entry for STAT3 (Homo sapiens)
Gene name (HAGRID: 22)
- HGNC symbol
- STAT3
- Aliases
- APRF
- Common name
- signal transducer and activator of transcription 3 (acute-phase response factor)
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
- Description
Transcription factors like those of the STAT family are activated by growth factors and cytokines. Their roles in intracellular signalling pathways suggest factors such as STAT3 might be involved in ageing and/or age-related disease [266]. Expression levels of JAK-STAT signalling targets is increased with age, and STAT3 has been implicated in the regulation of self-renewal and stem cell fate in several tissues. Knockdown or pharmacological inhibition of the JAK-STAT enhances satellite stem cell division potential resulting in better muscle regeneration [3635]. STAT3 has been associated with age-related heart failure in mice [270].
Cytogenetic information
- Cytogenetic band
- 17q21.31
- Location
- 42,313,325 bp to 42,388,495 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001659; temperature homeostasis
GO:0001754; eye photoreceptor cell differentiation
GO:0006355; regulation of transcription, DNA-templated
GO:0006357; regulation of transcription from RNA polymerase II promoter
GO:0006606; protein import into nucleus
GO:0006928; movement of cell or subcellular component
GO:0006953; acute-phase response
GO:0007165; signal transduction
GO:0007259; JAK-STAT cascade
GO:0007399; nervous system development
And 49 more GO terms Cellular component: GO:0000790; nuclear chromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005743; mitochondrial inner membrane
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0090575; RNA polymerase II transcription factor complex
Function: GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001103; RNA polymerase II repressing transcription factor binding
GO:0001228; transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003677; DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0004871; signal transducer activity
GO:0004879; RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0019901; protein kinase binding
And 8 more GO terms
Protein interactions and network
- Protein-protein interacting partners in GenAge
- GHR, IGF1R, PTPN11, NFKB2, STAT5B, STAT3, HDAC3, PTPN1, EGFR, ERBB2, PDGFRB, PRKCD, RET, CREBBP, HIF1A, HSP90AA1, NR3C1, NFKB1, CEBPB, EP300, PML, AR, RB1, RELA, SIRT1, HDAC1, MAPK8, PTK2, FGFR1, SP1, JUN, HESX1, PIK3R1, APEX1, SIN3A, HDAC2, JAK2, ESR1, MTOR, HIC1, CDKN1A, PDGFRA
- STRING interaction network
Retrieve sequences for STAT3
Homologs in model organisms
- Caenorhabditis elegans
- sta-1
- Danio rerio
- stat3
- Drosophila melanogaster
- Stat92E
- Mus musculus
- Stat3
- Rattus norvegicus
- Stat3
In other databases
- GenAge model organism genes
- A homolog of this gene for Drosophila melanogaster is present as Stat92E
- GenAge microarray genes
- This gene is present as STAT3
- CellAge
- This gene is present as STAT3
Selected references
External links
- EPD
- ORF Accession
- NM_003150
- CDS Accession
- NP_003141
- OMIM
- 102582
- HPRD
- 00026
- Ensembl
- STAT3
- UniProt/Swiss-Prot
- STAT3_HUMAN
- GeneCards
- STAT3
- Entrez Gene
- 6774
- GenAtlas
- STAT3
- Internet
- Search Google