- Symbol
- CHL1
- Aliases
- CTF1; LPA9; MCM12
- Name
- Chl1p
- Organism
- Saccharomyces cerevisiae (AnAge)
- Known functions and activities
- Required to establish sister-chromatid pairing
- Observations
- It may modulate transcriptional silencing in the presence of Sir proteins. Knockouts exhibit a shortened lifespan and are hypersensitivity to heat stress.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Knockout
- Longevity Category
- Necessary for fitness
- Primary reference
-
- Observations
- Mean chronological lifespan decreased in the a strain by less than 50% but more than 15%
- % change in avg or median lifespan
- Mean chronological lifespan is 15%-50% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Deletion
- Longevity Category
- Necessary for fitness
- Primary reference
-
- LongevityMap
- A homolog of this gene for Homo sapiens is present as BRIP1
- CellAge gene expression
- A homolog of this gene for Homo sapiens is present as DDX11
- A homolog of this gene for Homo sapiens is present as BRIP1
- Caenorhabditis elegans
- rtel-1
- Caenorhabditis elegans
- dog-1
- Caenorhabditis elegans
- chl-1
- Danio rerio
- ddx11
- Danio rerio
- brip1
- Danio rerio
- rtel1
- Drosophila melanogaster
- CG11403
- Drosophila melanogaster
- CG4078
- Homo sapiens
- RTEL1-TNFRSF6B
- Homo sapiens
- BRIP1
- Homo sapiens
- DDX11
- Homo sapiens
- RTEL1
- Mus musculus
- Brip1
- Mus musculus
- Ddx11
- Mus musculus
- Rtel1
- Rattus norvegicus
- Ddx11
- Rattus norvegicus
- Brip1
- Rattus norvegicus
- Rtel1
- Schizosaccharomyces pombe
- chl1
- Saccharomyces Genome Database
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (856099)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for CHL1 (Saccharomyces cerevisiae)