Cell Senescence Entries for TOP1

Cell Types
Lung fibroblast
Cell Lines
IMR-90, WI-38
Cancer Cell?
No
Method
Knockout
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Humbert et al. (2009) A genetic screen identifies topoisomerase 1 as a regulator of senescence. Cancer Res 69(10)4101-6 (PubMed)

TOP1 Gene Information

HGNC symbol
TOP1 
Aliases
 
Common name
DNA topoisomerase I 
Entrez Id
7150
Description
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008].

TOP1 Ontologies

Gene Ontology
Process: GO:16310; phosphorylation
GO:12501; programmed cell death
GO:6265; DNA topological change
GO:7623; circadian rhythm
GO:48511; rhythmic process
GO:32922; circadian regulation of gene expression
GO:6338; chromatin remodeling
GO:9410; response to xenobiotic stimulus
GO:7059; chromosome segregation
GO:6260; DNA replication
GO:18105; peptidyl-serine phosphorylation
GO:40016; embryonic cleavage
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:1650; fibrillar center
GO:5730; nucleolus
GO:5694; chromosome
GO:932; P-body
GO:228; nuclear chromosome
GO:32993; protein-DNA complex
GO:5737; cytoplasm
GO:43204; perikaryon
Function: GO:3723; RNA binding
GO:16853; isomerase activity
GO:3677; DNA binding
GO:5515; protein binding
GO:3916; DNA topoisomerase activity
GO:3917; DNA topoisomerase type I (single strand cut, ATP-independent) activity
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:3682; chromatin binding
GO:19904; protein domain specific binding
GO:5524; ATP binding
GO:3690; double-stranded DNA binding
GO:3697; single-stranded DNA binding
GO:4674; protein serine/threonine kinase activity
GO:97100; supercoiled DNA binding
Hide GO terms

Homologs of TOP1 in Model Organisms

Caenorhabditis elegans
top-1
Danio rerio
top1mt
Drosophila melanogaster
Top1
Mus musculus
Top1
Rattus norvegicus
Top1
Rattus norvegicus
Top1
Saccharomyces cerevisiae
TOP1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as top-1
  • A homolog of this gene for Saccharomyces cerevisiae is present as TOP1
GenAge human genes
  • This gene is present as TOP1

External links

OMIM
126420
Ensembl
ENSG00000198900
Entrez Gene
7150
UniGene
472737
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TOP1
GeneCards
TOP1