LongevityMap variant
Entry Details
- Longevity Association
- Significant
- Population
- American (Georgia and Louisiana populations from African and European origin)
- Study Design
- Haplotype analysis was performed in three candidate genes, and the haplotype combinations were tested for association with exceptional longevity in the Georgia Centenarian Study (n=650) and Louisiana Healthy Aging Study (n=869)
- Conclusions
- An HRAS1 haplotype enhanced the effect of an APOE haplotype on exceptional survival, and a LASS1 haplotype further augmented its magnitude. These results were replicated in a second population.
- Identifier
- HRAS
- In Other Studies (IDs)
- 1157 3471
- Cytogenetic Location
- 11p15.5
- UCSC Genome Browser
- View 11p15.5 on the UCSC genome browser
Gene details
- HGNC symbol
- HRAS
- Aliases
- CTLO; HAMSV; HRAS1; RASH1; p21ras; C-H-RAS; H-RASIDX; C-BAS/HAS; C-HA-RAS1
- Common name
- HRas proto-oncogene, GTPase
- Description
- This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 3
- OMIM
- 190020
- Ensembl
- ENSG00000174775
- UniProt/Swiss-Prot
- RASH_HUMAN
- Entrez Gene
- 3265
- UniGene
- 37003
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- let-60
- Danio rerio
- hrasb
- Danio rerio
- hrasa
- Drosophila melanogaster
- Ras85D
- Mus musculus
- Hras
- Rattus norvegicus
- Hras
- Rattus norvegicus
- Hras
- Saccharomyces cerevisiae
- RAS2
- Saccharomyces cerevisiae
- RAS1