LongevityMap variant

Entry Details

Longevity Association: Non-significant
Population: American (Georgia and Louisiana populations from African and European origin)
Study Design: Subjects were recruited and stratified according to their genetically inferred ethnic affiliation to account for population structure. Haplotype analysis was performed in three candidate genes, and the haplotype combinations were tested for association with exceptional longevity.
Conclusions: LASS1 and HRAS1 were not individually associated with longevity

HGNC symbol: HRAS
Aliases: CTLO; HAMSV; HRAS1; RASH1; p21ras; C-H-RAS; H-RASIDX; C-BAS/HAS; C-HA-RAS1
Common name: HRas proto-oncogene, GTPase
Description: This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008]
Other longevity studies of this gene: 3
OMIM: 190020
Ensembl: ENSG00000174775
UniProt/Swiss-Prot: RASH_HUMAN
Entrez Gene: 3265
UniGene: 37003
HapMap: View on HapMap

GenAge model organism genes

GenAge human genes

CellAge

Jazwinski et al. (2010)