LongevityMap variant

Entry Details

Longevity Association: Significant
Population: Italian
Study Design: Inherited mtDNA markers were analyzed between a sample of individuals selected for successful aging and longevity (212 subjects older than 100 years and in good clinical condition) and a sample of 275 younger individuals (20–75 years, median age 38 years) carefully matched as to sex and geographic origin
Conclusions: Male centenarians emerged in northern Italy as a particular sample: 1) mtDNA haplogroup frequency distribution was different between centenarians and younger individuals (P=0.017 by permutation tests); and 2) the frequency of the J haplogroup was notably higher in centenarians than in younger individuals (P=0.0052 by Fisher exact test). MtDNA inherited variability could play a role in successful aging and longevity.

HGNC symbol: TP53
Aliases: P53; BCC7; LFS1; TRP53
Common name: tumor protein p53
Description: This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
Other longevity studies of this gene: 47
OMIM: 191170
Ensembl: ENSG00000141510
UniProt/Swiss-Prot: A0A087WT22_HUMAN
Entrez Gene: 7157
UniGene: 437460
HapMap: View on HapMap

GenAge model organism genes

GenAge human genes

CellAge

De Benedictis et al. (1999)