LongevityMap Gene

Population

A genome-wide linkage scan on human longevity was performed in 279 families with multiple long-lived siblings

Study Design

Conclusions

One locus on chromosome 3p24-22 had genome-wide significance

Reference

Study 2

Longevity Association

Population

A genome-wide linkage scan on human longevity was performed in 279 families with multiple long-lived siblings

Study Design

Conclusions

One locus on chromosome 9q31-34 was borderline significant and a peak on 12q24 was detected in a subset of the data. There was also modest evidence for a peak on 4q22-25.

Reference

Study 3

Longevity Association

Population

Genome-wide linkage scan in 2118 European nonagenarian sibships and younger controls from various European studies followed by genome-wide association study in a subgroup of 1228 unrelated nonagenarian and 1907 geographically matched controls

Study Design

Conclusions

Four regions showed linkage to longevity (14q11.2, 17q12-q22, 19p13.3-p13.11 and 19q13.11-q13.32)

Reference

Study 4

Longevity Association

Population

Four regions showed linkage to longevity (14q11.2, 17q12-q22, 19p13.3-p13.11 and 19q13.11-q13.32)

Study Design

Conclusions

Reference

Study 5

Longevity Association

Population

Four regions showed linkage to longevity (14q11.2, 17q12-q22, 19p13.3-p13.11 and 19q13.11-q13.32)

Study Design

Conclusions

Reference

Study 6

Longevity Association

Population

Four regions showed linkage to longevity (14q11.2, 17q12-q22, 19p13.3-p13.11 and 19q13.11-q13.32)

Study Design

Conclusions

Reference

Study 7

Longevity Association

Population

Genome-wide scan for linkage in 308 individuals belonging to 137 sibships demonstrating exceptional longevity, predominantly of European descent

Study Design

Conclusions

Significant evidence for linkage was noted for chromosome 4 at D4S1564

Indentifier

D4S1564

Reference

Study 8

Longevity Association: Significant
Population: Italian (Central)
Study Design: A cross-sectional population study of 1072 individuals (18–106 years old) was performed and TP53 variants were analyzed
Conclusions: The variant rs1042522 affects females longevity, showing significant associations with longevity in the comparison of individuals >91 years old with individuals aged 73-91 years old. The TP53 P72 allele is significantly underrepresented in the >91 years old women group.
Indentifier

Study 9

Longevity Association

Twenty-eight mtDNA haplogroups were studied in 463 individuals with exceptional longevity (>95 years). As controls, 926 individuals aged 60-69 years (elderly group) and 463 individuals aged 40-49 years (middle-aged group) were used.

Population

Chinese

Study Design

Conclusions

M9 haplogroups in longevity subjects were reduced and a decreasing trend of N9 frequency was also observed. An increasing trend of D4 frequency and a decreasing trend of B4a frequency were observed in females. None of the associations were significant, however, after controlling for multiple testing.

Reference

Study 15

Longevity Association

The mtDNA of ten bama centenarians were sequenced and seven novel variations were identified. 313 individuals(113 samples in the 90-110 y, 75 between 80-89 y and 125 between 10-79 y) were involved for the analysis of 26 variations in mtDNA D-loop and several serum parameters.

Population

Chinese (Guangxi Bama)

Study Design

Conclusions

The frequency of mt146A had no significant difference among the three age groups(90-110 y, 80-89 y and 10-79 y) (P > 0.005), neither with the mt5178A/C polymorphism (P > 0.05)

Indentifier

mt146A

Reference

Study 16

Longevity Association

The mtDNA haplogroups were studied in 700 more than 85-year-old subjects to identify the association with frailty and mortality

Population

English (Newcastle)

Study Design

Conclusions

No association between mtDNA haplogroups and either frailty or survival beyond age 85 or any informative biomarker of aging

Reference

Study 17

Longevity Association

Population

A whole-genome scan for genetic linkage was performed in 325 individuals who exhibited high levels of both familial longevity and individual longevity

Study Design

Conclusions

There were no significant results after correcting for multiple testing. The strongest signal was observed in marker D3S3547, in 3p24.1, and other suggestive peaks were observed in 18q23-24, 8q23, and 17q21.

Indentifier

D3S3547

Reference

Study 18

Longevity Association

Population

A whole-genome scan for genetic linkage was performed in 325 individuals who exhibited high levels of both familial longevity and individual longevity

Study Design

Conclusions

Reference

Study 19

Longevity Association

Population

A whole-genome scan for genetic linkage was performed in 325 individuals who exhibited high levels of both familial longevity and individual longevity

Study Design

Conclusions

Reference

Study 20

Longevity Association

Population

A whole-genome scan for genetic linkage was performed in 325 individuals who exhibited high levels of both familial longevity and individual longevity

Study Design

Conclusions

Reference

Study 21

Longevity Association

556 longevous individuals (354 females, 90-108 years, mean ± SD: 94.59 ± 3.34 years) and 403 unrelated controls (199 females, 22-73 years, mean ± SD: 56.24 ± 7.81 years) were examined for the association between mtDNA C150T and longevity

Population

Chinese (Han)

Study Design

Conclusions

There was no significant association between C150T and longevity even when mtDNA haplogroups defined by C150T and gender were taken into account

Indentifier

MtC150T

Reference

Study 22

Longevity Association

The correlation between mitochondrial polymorphisms and the longevity phenotype was analyzed in 112 Japanese semi-supercentenarians and 672 previous published sequences from individuals with non-disease phenotypes

Population

Japanese

Study Design

Conclusions

mtSNP 14979C (Cytb: Ile78Thr) in D4a was identified to be correlated with extreme longevity

Indentifier

14979C

Reference

Study 23

Longevity Association

The frequencies of mtDNA haplogroups and haplogroup clusters were examined among elderly subjects and controls in a Finnish population: 225 persons aged 90 or 91 years (Vitality 90+, 179 women, 400 mid-age controls (18–65 years; mean age: 40.5 years)) and 257 infants (2–12 months; mean: 6.5 months))

Population

Finnish

Study Design

Conclusions

Haplogroup H was less frequent among the Vitality 90+ cases than among the middle-aged subjects (P=0.001) and infants (P=0.00001), whereas haplogroups J, U and K were more frequent. Haplogroup clusters also differed between Vitality 90+ and both the middle-aged subjects (P=0.002) and infants (P=0.00001), the frequency of haplogroup cluster HV being lower in the former and that of UK and WIX being higher. MtDNA haplogroups or haplogroup clusters were associated with longevity.

Reference

Study 24

Longevity Association

Inherited mtDNA markers were analyzed between a sample of individuals selected for successful aging and longevity (212 subjects older than 100 years and in good clinical condition) and a sample of 275 younger individuals (20–75 years, median age 38 years) carefully matched as to sex and geographic origin

Population

Italian

Study Design

Conclusions

Male centenarians emerged in northern Italy as a particular sample: 1) mtDNA haplogroup frequency distribution was different between centenarians and younger individuals (P=0.017 by permutation tests); and 2) the frequency of the J haplogroup was notably higher in centenarians than in younger individuals (P=0.0052 by Fisher exact test). MtDNA inherited variability could play a role in successful aging and longevity.

Reference

Study 25

Longevity Association: Significant
Population: Italian (Northern)
Study Design: The rs1333049 polymorphism was examined in a sample of 80 healthy centenarians (100-104y, 41 females), 218 patients younger than 40 who had experienced an acute myocardial infarction (22-39y, 53 females), and a control group of 258 healthy young volunteers (22–39y, 120 females) matched to acute myocardial infarction patients for age and sex
Conclusions: The frequency of the C allele of rs1333049 was significantly lower in centenarians compared to young controls, whereas acute myocardial infarction patients showed a higher frequency. After adjustment for gender and vascular risk factors, the C allele of rs1333049 remained significantly associated with a reduced likelihood to reach longevity: Odds ratio 0.64, 95% confidence interval (CI) 0.39-0.89, p < 0.01. The rs1333049 polymorphism may influence successful longevity, possibly by modulating the risk of age-related disorders.
Indentifier

Study 26

Longevity Association: Significant
Population: Danish
Study Design: Participants (n = 9,219) of the Copenhagen City Heart Study were genotyped for the p53 Arg72Pro polymorphism. Then the morbidity of 6 subtypes of cancer and mortality were assessed for each genotype.
Conclusions: The risk of hematologic cancer increased 2-fold in Arg/Pro heterozygotes vs. Arg/Arg homozygotes (p < 0.001), with a similar trend in Pro/Pro homozygotes. The overall 12-year survival after blood sampling was increased in Arg/Pro heterozygotes with 3% (p = 0.003) and in Pro/Pro homozygotes with 6% (p = 0.002) vs. Arg/Arg homozygotes. The cumulative 5-year mortality after a cancer diagnosis was reduced in Arg/Pro heterozygotes and Pro/Pro homozygotes vs. Arg/Arg homozygotes by 9% (p = 0.003) and 13% (p = 0.03). These results suggest a better prognosis in Arg/Pro heterozygotes and Pro/Pro homozygotes vs. Arg/Arg homozygotes after the diagnosis of cancer or other life-threatening disease.
Indentifier

Study 27

Longevity Association

European (Danish, Finnish, South Italian and Greek)

Population

Study Design

mtDNA sequences were analyzed in 4239 European individuals. 1292 individuals (646 ultranonagenarians and 646 controls) were selected for complete sequencing. The mtDNA subhaplogroups were determined in remaining 2947 samples (1449 ultranonagenarians and 1498 controls) to verify possible haplogroup association with longevity and the distribution pattern among European counties.

Conclusions

The distribution of H2, T2 haplogroup in female and H1, J2 in male showed differences between older subjects and younger controls, but no association was detectable when corrected for multiple test. Mitochondrial DNA variation does affect human longevity, but its effect is heavily influenced by the interaction between mutations concomitantly occurring on different mtDNA genes.

Reference

Study 28

Longevity Association: Significant
Population: Spanish
Study Design: Allele and genotype distributions of rs1333049 were compared in centenarians and younger adults (without (healthy) or with CAD) in two independent cohorts: Spanish and Japanese.
Conclusions: The frequency of the GG genotype in centenarians was higher than either healthy or CAD controls in Spanish. In the Japanese cohort, C allele did not differ between centenarians and healthy controls, but it was significantly lower in centenarians than in CAD controls.
Indentifier

Study 29

Longevity Association: Significant
Population: Japanese
Study Design: Allele and genotype distributions of rs1333049 were compared in centenarians and younger adults (without (healthy) or with CAD) in two independent cohorts: Spanish and Japanese.
Conclusions: The frequency of the GG genotype in centenarians was higher than either healthy or CAD controls in Spanish. In the Japanese cohort, C allele did not differ between centenarians and healthy controls, but it was significantly lower in centenarians than in CAD controls.
Indentifier

Study 30

Longevity Association

GSTT1 (Glutathione S-transferase theta 1) deletion and the simultaneous presence of the three p53 polymorphisms were examined in 66 nonagenarians and centenarians in good health and in a sample of 150 young healthy volunteers of the same ethnic group

Population

Italian (Northern)

Study Design

Conclusions

No significant differences were found for individual genes. However, the absence of any p53 polymorphisms and of GSTT1 deletion, and the simultaneous presence of the three p53 polymorphisms and of GSTT1 deletion, were much more frequent in young subjects than in centenarians (41.5% versus 26.9% and 8.8% versus 3.8%, respectively).

Indentifier

TP53

Reference

Study 31

Longevity Association

Genome-wide association study comparing 664,472 autosomal SNPs in 763 long-lived individuals (mean age: 99.7 years) and 1085 controls (mean age: 60.2 years). Top SNPs from the GWAS were further investigated in an independent German sample comprised of 754 long-lived individuals (mean age: 96.9 years) and 860 controls (mean age: 67.3 years).

Population

German

Study Design

Conclusions

Fifteen SNPs had indicative association with longevity, even if not statistically significant after correcting for multiple hypothesis testing. None of these SNPs were validated in the follow-up analysis. Since rs12741354 (in ASTN1) was nearly significant, it was further investigated in French centenarians but it failed to be associated with longevity.

Reference

Study 32

Longevity Association

A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).

Population

Italian (Southern)

Study Design

Conclusions

After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.

Reference

Study 33

Longevity Association

Polymorphic restriction enzyme sites within a 2643 bp region of mtDNA were identified by PCR-RFLP in 129 aged individuals (80- 97y, 70% female) and 100 controls (19- 45y, 59% female). Then, genetic haplotypes for a healthy aged and a younger control cohort of patients was constructed to find out the relationship between longevity and mtDNA polymorphisms.

Population

Irish

Study Design

Conclusions

The were no significant frequency differences between the two age groups for 46 identified haplotypes. However, the branch of haplotypes defined by 16389g displayed a significant increased frequency in the aged samples (P=0.015). Inversely, the branch of haplotypes defined by 16000g displayed a significant decreased frequency in the aged samples (P=0.011).

Indentifier

16389g

Reference

Study 34

Longevity Association

The were no significant frequency differences between the two age groups for 46 identified haplotypes. The previously reported longevity associated European J haplogroup was not found at an increased frequency within the Irish aged population (P=0.36). The polymorphism (mt5178A) associated with longevity in the Japanese was not found in the Irish population, while the polymorphism (mt9055A) associated with successful ageing in French centenarians was found at a noticeable but not significant (P=0.164) increased frequency in the Irish aged population compared to the younger control group.

Population

Irish

Study Design

Conclusions

Indentifier

mt9055A

Reference

Study 35

Longevity Association: Non-significant
Population: Danish
Study Design: 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
Conclusions: The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
Indentifier

Study 36

Longevity Association

Population

A genome-wide linkage scan on human longevity was performed in 279 families with multiple long-lived siblings

Study Design

Conclusions

One locus on chromosome 9q31-34 was borderline significant and a peak on 12q24 was detected in a subset of the data. There was also modest evidence for a peak on 4q22-25.

Reference

Study 37

Longevity Association

Population