Cell Senescence Entries for TP53
- Cell Types
- Bladder cancer
- Cell Lines
- EJ
- Cancer Cell?
- Yes
- Method
- Overexpression
- Type of senescence
- Oncogene-induced, Replicative, Stress-induced
- Senescence Effect
- Induces
- Primary Reference
- Sugrue et al. (1997) Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53. Proc Natl Acad Sci U S A 94(18)9648-53 (PubMed)
TP53 Gene Information
- HGNC symbol
- TP53
- Aliases
- LFS1; p53
- Common name
- tumor protein p53
- Entrez Id
- 7157
- Description
- This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016].
TP53 Ontologies
- Gene Ontology
-
Process: GO:7049; cell cycle
GO:6355; regulation of transcription, DNA-templated
GO:6915; apoptotic process
GO:12501; programmed cell death
GO:45893; positive regulation of transcription, DNA-templated
GO:48511; rhythmic process
GO:51262; protein tetramerization
GO:10628; positive regulation of gene expression
GO:45892; negative regulation of transcription, DNA-templated
GO:6974; cellular response to DNA damage stimulus
GO:45944; positive regulation of transcription by RNA polymerase II
And 127 more GO terms Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5783; endoplasmic reticulum
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5759; mitochondrial matrix
GO:16605; PML body
GO:5815; microtubule organizing center
GO:16020; membrane
GO:16021; integral component of membrane
GO:5739; mitochondrion
And 12 more GO terms Function: GO:46872; metal ion binding
GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:976; transcription cis-regulatory region binding
GO:5515; protein binding
GO:8270; zinc ion binding
GO:31625; ubiquitin protein ligase binding
GO:42802; identical protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:19899; enzyme binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
And 29 more GO terms
Homologs of TP53 in Model Organisms
- Danio rerio
- tp53
- Mus musculus
- Trp53
- Rattus norvegicus
- LOC100910954
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Trp53
- GenAge human genes
- This gene is present as TP53
- LongevityMap
- This gene is present as TP53
External links
- OMIM
- 191170
- Ensembl
- ENSG00000141510
- Entrez Gene
- 7157
- UniGene
- 740601
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- TP53
- GeneCards
- TP53