Cell Senescence Entries for TP53

Cell Types
Bladder cancer
Cell Lines
EJ
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Oncogene-induced, Replicative, Stress-induced
Senescence Effect
Induces
Primary Reference
Sugrue et al. (1997) Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53. Proc Natl Acad Sci U S A 94(18)9648-53 (PubMed)

TP53 Gene Information

HGNC symbol
TP53 
Aliases
LFS1; p53 
Common name
tumor protein p53 
Entrez Id
7157
Description
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016].

TP53 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:6355; regulation of transcription, DNA-templated
GO:6915; apoptotic process
GO:12501; programmed cell death
GO:45893; positive regulation of transcription, DNA-templated
GO:48511; rhythmic process
GO:51262; protein tetramerization
GO:10628; positive regulation of gene expression
GO:45892; negative regulation of transcription, DNA-templated
GO:6974; cellular response to DNA damage stimulus
GO:45944; positive regulation of transcription by RNA polymerase II
And 127 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5783; endoplasmic reticulum
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5759; mitochondrial matrix
GO:16605; PML body
GO:5815; microtubule organizing center
GO:16020; membrane
GO:16021; integral component of membrane
GO:5739; mitochondrion
And 12 more GO terms
Function: GO:46872; metal ion binding
GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:976; transcription cis-regulatory region binding
GO:5515; protein binding
GO:8270; zinc ion binding
GO:31625; ubiquitin protein ligase binding
GO:42802; identical protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:19899; enzyme binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
And 29 more GO terms
Show all GO terms

Homologs of TP53 in Model Organisms

Danio rerio
tp53
Mus musculus
Trp53
Rattus norvegicus
LOC100910954

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Trp53
GenAge human genes
  • This gene is present as TP53
LongevityMap
  • This gene is present as TP53

External links

OMIM
191170
Ensembl
ENSG00000141510
Entrez Gene
7157
UniGene
740601
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TP53
GeneCards
TP53