LongevityMap variant

Entry Details

Longevity Association: Significant
Population: Finnish
Study Design: The frequencies of mtDNA haplogroups and haplogroup clusters were examined among elderly subjects and controls in a Finnish population: 225 persons aged 90 or 91 years (Vitality 90+, 179 women, 400 mid-age controls (18–65 years; mean age: 40.5 years)) and 257 infants (2–12 months; mean: 6.5 months))
Conclusions: Haplogroup H was less frequent among the Vitality 90+ cases than among the middle-aged subjects (P=0.001) and infants (P=0.00001), whereas haplogroups J, U and K were more frequent. Haplogroup clusters also differed between Vitality 90+ and both the middle-aged subjects (P=0.002) and infants (P=0.00001), the frequency of haplogroup cluster HV being lower in the former and that of UK and WIX being higher. MtDNA haplogroups or haplogroup clusters were associated with longevity.

HGNC symbol: TP53
Aliases: P53; BCC7; LFS1; TRP53
Common name: tumor protein p53
Description: This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
Other longevity studies of this gene: 47
OMIM: 191170
Ensembl: ENSG00000141510
UniProt/Swiss-Prot: A0A087WT22_HUMAN
Entrez Gene: 7157
UniGene: 437460
HapMap: View on HapMap

GenAge model organism genes

GenAge human genes

CellAge

Niemi et al. (2003)