LongevityMap variant
Entry Details
- Longevity Association
- Non-significant
- Population
- Chinese (Guangxi Bama)
- Study Design
- The mtDNA of ten bama centenarians were sequenced and seven novel variations were identified. 313 individuals(113 samples in the 90-110 y, 75 between 80-89 y and 125 between 10-79 y) were involved for the analysis of 26 variations in mtDNA D-loop and several serum parameters.
- Conclusions
- The frequency of mt146A had no significant difference among the three age groups(90-110 y, 80-89 y and 10-79 y) (P > 0.005), neither with the mt5178A/C polymorphism (P > 0.05)
- Identifier
- mt146A
- Cytogenetic Location
- 17p13.1
- UCSC Genome Browser
- View 17p13.1 on the UCSC genome browser
Gene details
- HGNC symbol
- TP53
- Aliases
- P53; BCC7; LFS1; TRP53
- Common name
- tumor protein p53
- Description
- This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
- Other longevity studies of this gene
- 47
- OMIM
- 191170
- Ensembl
- ENSG00000141510
- UniProt/Swiss-Prot
- A0A087WT22_HUMAN
- Entrez Gene
- 7157
- UniGene
- 437460
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- tp53
- Mus musculus
- Trp53
- Rattus norvegicus
- LOC100910954