LongevityMap variant
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 38 genes (311 SNPs) belonging to pro-antioxidant pathways were investigated for the association with physical and cognitive performances in a Cohort of 1089 Danish nonagenarians. For each gene analyzed in the pro-antioxidant pathway, the influence on longitudinal survival was tested.
- Conclusions
- No gene found associated with a functional phenotype showed a corresponding association with survival in the whole cohort. NDUFS1, TXNRD1, SOD2 and UCP3 were found significantly associated with lifespan in the female cohort. No association with survival was reported in males for genes belonging to the pro-oxidant pathway here analyzed.
- HGNC symbol
- PON1
- Aliases
- ESA; PON; MVCD5
- Common name
- paraoxonase 1
- Description
- The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3. [provided by RefSeq, Oct 2008]
- Other longevity studies of this gene
- 31
- OMIM
- 168820
- Ensembl
- ENSG00000005421
- UniProt/Swiss-Prot
- PON1_HUMAN
- Entrez Gene
- 5444
- UniGene
- 370995
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- poml-4
- Caenorhabditis elegans
- mec-6
- Caenorhabditis elegans
- poml-2
- Caenorhabditis elegans
- poml-3
- Danio rerio
- pon3.2
- Danio rerio
- pon3.2
- Danio rerio
- pon2
- Danio rerio
- pon1
- Mus musculus
- Pon1
- Rattus norvegicus
- Pon1
- GenAge human genes
- This gene is present as PON1
- CellAge
- This gene is present as PON1
Dato et al. (2014)
Other variants which are also part of this study
