GenAge entry for PON1 (Homo sapiens)
Gene name (HAGRID: 142)
- HGNC symbol
- PON1
- Aliases
- ESA; PON
- Common name
- paraoxonase 1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
PON1 hydrolyzes toxic compounds and is associated with high-density lipoproteins. Mice without PON1 are more susceptible to some toxic agents and, when fed a high-fat, high-cholesterol diet, display atherosclerosis [708]. Allelic variants in the human PON1 gene have been linked to longevity [706] and neurodegenerative diseases [707]. A role in human ageing is possible even if unverified.
Cytogenetic information
- Cytogenetic band
- 7q21.3
- Location
- 95,298,357 bp to 95,324,572 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0008203; cholesterol metabolic process
GO:0009605; response to external stimulus
GO:0009636; response to toxic substance
GO:0010875; positive regulation of cholesterol efflux
GO:0016311; dephosphorylation
GO:0019439; aromatic compound catabolic process
GO:0031667; response to nutrient levels
GO:0032411; positive regulation of transporter activity
GO:0034445; negative regulation of plasma lipoprotein particle oxidation
GO:0046395; carboxylic acid catabolic process
GO:0046434; organophosphate catabolic process
And 5 more GO terms Cellular component: GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0034364; high-density lipoprotein particle
GO:0034366; spherical high-density lipoprotein particle
GO:0043231; intracellular membrane-bounded organelle
GO:0070062; extracellular exosome
GO:0072562; blood microparticle
Function: GO:0004063; aryldialkylphosphatase activity
GO:0004064; arylesterase activity
GO:0005509; calcium ion binding
GO:0005543; phospholipid binding
GO:0042803; protein homodimerization activity
GO:0102007; acyl-L-homoserine-lactone lactonohydrolase activity
Protein interactions and network
Retrieve sequences for PON1
Homologs in model organisms
- Caenorhabditis elegans
- poml-4
- Caenorhabditis elegans
- mec-6
- Caenorhabditis elegans
- poml-2
- Caenorhabditis elegans
- poml-3
- Danio rerio
- pon3.2
- Danio rerio
- pon3.2
- Danio rerio
- pon2
- Danio rerio
- pon1
- Mus musculus
- Pon1
- Rattus norvegicus
- Pon1
In other databases
Selected references
External links
- EPD
- ORF Accession
- NM_000446
- CDS Accession
- NP_000437
- OMIM
- 168820
- HPRD
- 01351
- Ensembl
- PON1
- UniProt/Swiss-Prot
- PON1_HUMAN
- GeneCards
- PON1
- Entrez Gene
- 5444
- GenAtlas
- PON1
- Internet
- Search Google