Cell Senescence Entries for PON1
- Cell Types
- Dermal microvascular endothelial
- Cell Lines
- HDMEC
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Lee et al. (2013) Knockdown of paraoxonase 1 expression influences the ageing of human dermal microvascular endothelial cells. Exp Dermatol 21(9)682-7 (PubMed)
PON1 Gene Information
- HGNC symbol
- PON1
- Aliases
- ESA; PON
- Common name
- paraoxonase 1
- Entrez Id
- 5444
- Description
- This gene encodes a member of the paraoxonase family of enzymes and exhibits lactonase and ester hydrolase activity. Following synthesis in the kidney and liver, the enzyme is secreted into the circulation, where it binds to high density lipoprotein (HDL) particles and hydrolyzes thiolactones and xenobiotics, including paraoxon, a metabolite of the insecticide parathion. Polymorphisms in this gene may be associated with coronary artery disease and diabetic retinopathy. The gene is found in a cluster of three related paraoxonase genes on chromosome 7. [provided by RefSeq, Aug 2017].
PON1 Ontologies
- Gene Ontology
-
Process: GO:16311; dephosphorylation
GO:51099; positive regulation of binding
GO:10875; positive regulation of cholesterol efflux
GO:46470; phosphatidylcholine metabolic process
GO:32411; positive regulation of transporter activity
GO:6629; lipid metabolic process
GO:8203; cholesterol metabolic process
GO:9636; response to toxic substance
GO:19439; aromatic compound catabolic process
GO:31667; response to nutrient levels
GO:46395; carboxylic acid catabolic process
And 4 more GO terms Cellular component: GO:5615; extracellular space
GO:5576; extracellular region
GO:34364; high-density lipoprotein particle
GO:70062; extracellular exosome
GO:72562; blood microparticle
GO:34366; spherical high-density lipoprotein particle
GO:43231; intracellular membrane-bounded organelle
Function: GO:46872; metal ion binding
GO:16787; hydrolase activity
GO:5509; calcium ion binding
GO:4064; arylesterase activity
GO:102007; acyl-L-homoserine-lactone lactonohydrolase activity
GO:42803; protein homodimerization activity
GO:5543; phospholipid binding
GO:4063; aryldialkylphosphatase activity
Homologs of PON1 in Model Organisms
- Caenorhabditis elegans
- poml-4
- Caenorhabditis elegans
- mec-6
- Caenorhabditis elegans
- poml-2
- Caenorhabditis elegans
- poml-3
- Danio rerio
- pon3.2
- Danio rerio
- pon3.2
- Danio rerio
- pon2
- Danio rerio
- pon1
- Mus musculus
- Pon1
- Rattus norvegicus
- Pon1
In other databases
External links
- OMIM
- 168820
- Ensembl
- ENSG00000005421
- Entrez Gene
- 5444
- UniGene
- 370995
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- PON1
- GeneCards
- PON1