LongevityMap variant
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
- Conclusions
- After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
- HGNC symbol
- PON1
- Aliases
- ESA; PON; MVCD5
- Common name
- paraoxonase 1
- Description
- The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3. [provided by RefSeq, Oct 2008]
- Other longevity studies of this gene
- 31
- OMIM
- 168820
- Ensembl
- ENSG00000005421
- UniProt/Swiss-Prot
- PON1_HUMAN
- Entrez Gene
- 5444
- UniGene
- 370995
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- poml-4
- Caenorhabditis elegans
- mec-6
- Caenorhabditis elegans
- poml-2
- Caenorhabditis elegans
- poml-3
- Danio rerio
- pon3.2
- Danio rerio
- pon3.2
- Danio rerio
- pon2
- Danio rerio
- pon1
- Mus musculus
- Pon1
- Rattus norvegicus
- Pon1
- GenAge human genes
- This gene is present as PON1
- CellAge
- This gene is present as PON1
Di Cianni et al. (2013)
Other variants which are also part of this study