GenAge entry for YWHAZ (Homo sapiens)

Gene name (HAGRID: 164)

HGNC symbol: YWHAZ
Aliases: KCIP-1; 14-3-3-zeta; YWHAD
Common name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description: YWHAZ is an adapter protein implicated in several signal transduction pathways [997]. Although YWHAZ has not been directly related to ageing, because it interacts with so many proteins, including many associated with ageing such as the INS/IGF1 pathway [996], it is possible that YWHAZ itself plays some role in human ageing.

Cytogenetic information

Cytogenetic band: 8q23.1
Location: 100,918,576 bp to 100,952,129 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0007165; signal transduction
GO:0030168; platelet activation
GO:0043066; negative regulation of apoptotic process
GO:0043488; regulation of mRNA stability
GO:0051683; establishment of Golgi localization
GO:0061024; membrane organization
GO:0090168; Golgi reassembly
GO:0098609; cell-cell adhesion
GO:1900740; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

Cellular component:	GO:0005615; extracellular space GO:0005634; nucleus GO:0005654; nucleoplasm GO:0005737; cytoplasm GO:0005739; mitochondrion GO:0005829; cytosol GO:0005913; cell-cell adherens junction GO:0005925; focal adhesion GO:0030659; cytoplasmic vesicle membrane GO:0042470; melanosome GO:0070062; extracellular exosome
	And 2 more GO terms

Function:

GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0019901; protein kinase binding
GO:0019904; protein domain specific binding
GO:0031625; ubiquitin protein ligase binding
GO:0042802; identical protein binding
GO:0044822; poly(A) RNA binding
GO:0098641; cadherin binding involved in cell-cell adhesion

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, TERT, IRS2, AKT1, EGFR, NCOR1, PRKCD, BRCA1, VCP, ABL1, EP300, PRKCA, XRCC6, GRB2, FOXO3, FOXO1, APP, RAD52, HSPA1B, MAPK8, YWHAZ, MAP3K5, MAPT, H2AFX, MTOR, CTNNB1, UCP3, UCP2, TP53BP1, SQSTM1
STRING interaction network

Retrieve sequences for YWHAZ

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: M117.3
Caenorhabditis elegans: ftt-2
Caenorhabditis elegans: par-5
Drosophila melanogaster: 14-3-3zeta
Mus musculus: Ywhaz
Rattus norvegicus: Ywhaz
Saccharomyces cerevisiae: BMH1
Saccharomyces cerevisiae: BMH2

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as ftt-2
A homolog of this gene for Caenorhabditis elegans is present as par-5
A homolog of this gene for Saccharomyces cerevisiae is present as BMH1
A homolog of this gene for Saccharomyces cerevisiae is present as BMH2

CellAge

This gene is present as YWHAZ