- Symbol
- SOD1
- Aliases
- CRS4
- Name
- Cu, Zn superoxide dismutase
- Organism
- Saccharomyces cerevisiae (AnAge)
- Known functions and activities
- Protects cells against oxygen toxicity
- Observations
- Overexpression of Sod1 and Sod2 extends survival by 30%.
- % change in avg or median lifespan
- Lifespan is 30% higher.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- Increasing the level of active Cu, Zn-Sod in yeast was found to require either growth in the presence of high copper, or the simultaneous overexpression of both SOD1 and CCS1 (the latter being the gene that encodes the chaperone dedicated to Cu(2+)-loading of Sod1p in vivo). Dual SOD1 + CCS1 overexpression elevated the levels of Cu,Zn-Sod activity six- to eight-fold in vegetative cultures. It also increased the optimized survival of stationary cells up to two-fold, showing this chronological lifespan is ultimately limited by oxidative stress. In contrast, several detrimental effects resulted when the SOD1 gene was overexpressed in the absence of either high copper or a simultaneous overexpression of CCS1. Both the chronological and the replicative lifespans were shortened; the cells displayed an abnormally high level of endogenous oxidative stress, resulting in a high rate of spontaneous mutation. Such harmful effects were all reversed through the overexpression of CCS1.
- Lifespan Effect
- Increase
- Genetic Manipulation
- Overexpression
- Longevity Category
- Pro-Longevity
- Primary reference
-
- Observations
- 40% decrease in replicative lifespan
- % change in avg or median lifespan
- Replicative lifespan is 40% lower.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- Deletion
- Longevity Category
- Necessary for fitness
- Primary reference
-
- GenAge model organism genes
- A homolog of this gene for Drosophila melanogaster is present as Sod
- A homolog of this gene for Caenorhabditis elegans is present as sod-1
- A homolog of this gene for Mus musculus is present as SOD3
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as SOD1
- GenDR gene manipulations
- This gene is present as SOD1
- LongevityMap
- A homolog of this gene for Homo sapiens is present as SOD1
- A homolog of this gene for Homo sapiens is present as SOD3
- CellAge
- A homolog of this gene for Homo sapiens is present as SOD1
- Caenorhabditis elegans
- sod-4
- Caenorhabditis elegans
- sod-1
- Caenorhabditis elegans
- sod-5
- Danio rerio
- sod1
- Danio rerio
- sod3a
- Danio rerio
- sod3b
- Danio rerio
- ccs
- Drosophila melanogaster
- Ccs
- Drosophila melanogaster
- Sod
- Drosophila melanogaster
- Sod3
- Homo sapiens
- SOD1
- Homo sapiens
- CCS
- Homo sapiens
- SOD3
- Mus musculus
- Sod1
- Mus musculus
- Ccs
- Mus musculus
- Sod3
- Rattus norvegicus
- Ccs
- Rattus norvegicus
- Sod3
- Rattus norvegicus
- Sod1
- Schizosaccharomyces pombe
- sod1
- Saccharomyces Genome Database
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (853568)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar