LongevityMap Gene

Gene details

HGNC symbol: SOD3
Aliases: EC-SOD
Common name: superoxide dismutase 3
Description: This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk. [provided by RefSeq, Oct 2015]
Cytogenetic Location: 4p15.2
UCSC Genome Browser: View 4p15.2 on the UCSC genome browser
OMIM: 185490
Ensembl: ENSG00000109610
UniProt/Swiss-Prot: A0A140VJU8_HUMAN
Entrez Gene: 6649
UniGene: 2420
1000 Genomes: 1000 Genomes

Homologs in model organisms

Danio rerio: sod3b
Drosophila melanogaster: Sod3
Mus musculus: Sod3
Rattus norvegicus: Sod3
Saccharomyces cerevisiae: SOD1

In other databases

GenAge model organism genes

A homolog of this gene for Saccharomyces cerevisiae is present as SOD1
A homolog of this gene for Mus musculus is present as SOD3

GenDR gene manipulations

A homolog of this gene for Saccharomyces cerevisiae is present as SOD1

Studies (3)

Significant/Non-significant: 0/3

Study 1

Longevity Association: Non-significant
Population: German
Study Design: 19 SNPs were examined in 1612 long-lived individuals (centenarians and nonagenarians) and 1104 younger controls as well as a subgroup of 748 centenarians from 1612 LLIs and 1104 younger controls.
Conclusions: No association was detected between the tested SNPs and the longevity phenotype, in the entire long-lived sample set nor in the centenarian subgroup analysis. There was no considerable influence of sequence variation in the SOD genes on human longevity in Germans.
Indentifier

Study 2

Longevity Association: Non-significant
Population: Italian (Southern)
Study Design: A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
Conclusions: After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
Indentifier

Study 3

Longevity Association: Non-significant
Population: Danish
Study Design: 38 genes (311 SNPs) belonging to pro-antioxidant pathways were investigated for the association with physical and cognitive performances in a Cohort of 1089 Danish nonagenarians. For each gene analyzed in the pro-antioxidant pathway, the influence on longitudinal survival was tested.
Conclusions: No gene found associated with a functional phenotype showed a corresponding association with survival in the whole cohort. NDUFS1, TXNRD1, SOD2 and UCP3 were found significantly associated with lifespan in the female cohort. No association with survival was reported in males for genes belonging to the pro-oxidant pathway here analyzed.
Indentifier