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Saccharomyces cerevisiaeGenAge entry for HCM1 (Saccharomyces cerevisiae)

Gene information (ID: 1870)

Symbol
HCM1
Name
Hcm1p
Organism
Saccharomyces cerevisiae (AnAge)

Potential relevance to longevity and/or ageing

Observations
Strong overexpression of HCM1 results in a 30% increase in yeast replicative lifespan when comparing to wild-type, while weaker overexpression has no effect on life span. Complementary, HCM1 deletion results in a 30% decrease in yeast replicative lifespan. Manipulation of HCM1 levels does not extend yeast chronological life span.
% change in avg or median lifespan
Mean replicative lifespan is 30% higher.
Lifespan Effect
Increase
Genetic Manipulation
Overexpression
Longevity Category
Pro-Longevity
Primary reference

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as daf-16
    • A homolog of this gene for Mus musculus is present as Foxm1
    • A homolog of this gene for Drosophila melanogaster is present as foxo
    GenAge human genes
    • A homolog of this gene for Homo sapiens is present as FOXM1
    • A homolog of this gene for Homo sapiens is present as FOXO1
    • A homolog of this gene for Homo sapiens is present as FOXO3
    • A homolog of this gene for Homo sapiens is present as FOXO4
    GenDR gene manipulations
    • A homolog of this gene for Drosophila melanogaster is present as foxo
    • A homolog of this gene for Mus musculus is present as Foxo3
    • A homolog of this gene for Caenorhabditis elegans is present as daf-16
    LongevityMap
    • A homolog of this gene for Homo sapiens is present as FOXO1
    • A homolog of this gene for Homo sapiens is present as FOXO3
    • A homolog of this gene for Homo sapiens is present as FOXO4
    CellAge
    • A homolog of this gene for Homo sapiens is present as FOXM1
    • A homolog of this gene for Homo sapiens is present as FOXO1
    • A homolog of this gene for Homo sapiens is present as FOXO3
    • A homolog of this gene for Homo sapiens is present as FOXO4
    CellAge gene expression
    • A homolog of this gene for Homo sapiens is present as FOXM1

    Homologs in other organisms

    Caenorhabditis elegans
    fkh-9
    Caenorhabditis elegans
    fkh-10
    Caenorhabditis elegans
    daf-16
    Caenorhabditis elegans
    pes-1
    Danio rerio
    foxo1a
    Danio rerio
    foxq2
    Danio rerio
    foxo1b
    Danio rerio
    si:dkey-11f5.5
    Danio rerio
    si:ch211-206a7.2
    Danio rerio
    foxo4
    Danio rerio
    foxo3b
    Danio rerio
    foxo3a
    Danio rerio
    foxm1
    Drosophila melanogaster
    foxo
    Drosophila melanogaster
    fd102C
    Homo sapiens
    FOXO3
    Homo sapiens
    FOXO1
    Homo sapiens
    FOXM1
    Homo sapiens
    FOXO4
    Homo sapiens
    FOXO6
    Mus musculus
    Foxm1
    Mus musculus
    Foxo4
    Mus musculus
    Foxo6
    Mus musculus
    Foxo3
    Mus musculus
    Foxo1
    Rattus norvegicus
    Foxo6
    Rattus norvegicus
    Foxm1
    Rattus norvegicus
    Foxo1
    Rattus norvegicus
    Foxo3
    Rattus norvegicus
    Foxo4
    Schizosaccharomyces pombe
    mei4

    External links

    Saccharomyces Genome Database
    Search
    Ensembl
    Search
    Entrez Gene
    View on Entrez Gene database (850429)
    Homologues
    Search HomoloGene
    UniProt
    Search
    Internet
    Search Google or Search Google Scholar