Cell Senescence Entries for FOXO1

Cell Types
Foreskin fibroblast
Cell Lines
NHDF
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Latorre et al. (2019) FOXO1 and ETV6 genes may represent novel regulators of splicing factor expression in cellular senescence. FASEB J 33(1)1086-1097 (PubMed)

FOXO1 Gene Information

HGNC symbol
FOXO1 
Aliases
FKH1; FKHR; FOXO1A 
Common name
forkhead box O1 
Entrez Id
2308
Description
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008].

FOXO1 Ontologies

Gene Ontology
Process: GO:43066; negative regulation of apoptotic process
GO:6355; regulation of transcription, DNA-templated
GO:6915; apoptotic process
GO:45892; negative regulation of transcription, DNA-templated
GO:30154; cell differentiation
GO:6974; cellular response to DNA damage stimulus
GO:45944; positive regulation of transcription by RNA polymerase II
GO:6914; autophagy
GO:45893; positive regulation of transcription, DNA-templated
GO:43065; positive regulation of apoptotic process
GO:122; negative regulation of transcription by RNA polymerase II
And 29 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5739; mitochondrion
GO:5829; cytosol
GO:785; chromatin
GO:5654; nucleoplasm
Function: GO:3677; DNA binding
GO:31625; ubiquitin protein ligase binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:3682; chromatin binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:8013; beta-catenin binding
GO:51721; protein phosphatase 2A binding
And 4 more GO terms
Show all GO terms

Homologs of FOXO1 in Model Organisms

Caenorhabditis elegans
daf-16
Danio rerio
foxo1a
Danio rerio
foxo1b
Drosophila melanogaster
foxo
Mus musculus
Foxo1
Rattus norvegicus
Foxo1
Saccharomyces cerevisiae
HCM1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as daf-16
  • A homolog of this gene for Drosophila melanogaster is present as foxo
  • A homolog of this gene for Saccharomyces cerevisiae is present as HCM1
GenAge human genes
  • This gene is present as FOXO1
GenDR gene manipulations
  • A homolog of this gene for Drosophila melanogaster is present as foxo
  • A homolog of this gene for Caenorhabditis elegans is present as daf-16
LongevityMap
  • This gene is present as FOXO1

External links

OMIM
136533
Ensembl
ENSG00000150907
Entrez Gene
2308
UniGene
370666
1000 Genomes
1000 Genomes
HPRD
GenAtlas
FOXO1
GeneCards
FOXO1