Cell Senescence Entries for FOXO1
- Cell Types
- Foreskin fibroblast
- Cell Lines
- NHDF
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Induces
- Primary Reference
- Latorre et al. (2019) FOXO1 and ETV6 genes may represent novel regulators of splicing factor expression in cellular senescence. FASEB J 33(1)1086-1097 (PubMed)
FOXO1 Gene Information
- HGNC symbol
- FOXO1
- Aliases
- FKH1; FKHR; FOXO1A
- Common name
- forkhead box O1
- Entrez Id
- 2308
- Description
- This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008].
FOXO1 Ontologies
- Gene Ontology
-
Process: GO:43066; negative regulation of apoptotic process
GO:6355; regulation of transcription, DNA-templated
GO:6915; apoptotic process
GO:45892; negative regulation of transcription, DNA-templated
GO:30154; cell differentiation
GO:6974; cellular response to DNA damage stimulus
GO:45944; positive regulation of transcription by RNA polymerase II
GO:6914; autophagy
GO:45893; positive regulation of transcription, DNA-templated
GO:43065; positive regulation of apoptotic process
GO:122; negative regulation of transcription by RNA polymerase II
And 29 more GO terms Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5739; mitochondrion
GO:5829; cytosol
GO:785; chromatin
GO:5654; nucleoplasm
Function: GO:3677; DNA binding
GO:31625; ubiquitin protein ligase binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:3682; chromatin binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:8013; beta-catenin binding
GO:51721; protein phosphatase 2A binding
And 4 more GO terms
Homologs of FOXO1 in Model Organisms
- Caenorhabditis elegans
- daf-16
- Danio rerio
- foxo1a
- Danio rerio
- foxo1b
- Drosophila melanogaster
- foxo
- Mus musculus
- Foxo1
- Rattus norvegicus
- Foxo1
- Saccharomyces cerevisiae
- HCM1
In other databases
- GenAge model organism genes
- GenAge human genes
- This gene is present as FOXO1
- GenDR gene manipulations
- LongevityMap
- This gene is present as FOXO1
External links
- OMIM
- 136533
- Ensembl
- ENSG00000150907
- Entrez Gene
- 2308
- UniGene
- 370666
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- FOXO1
- GeneCards
- FOXO1