GenAge entry for FOXO4 (Homo sapiens)

Gene name (HAGRID: 183)

HGNC symbol: FOXO4
Aliases: AFX1; MLLT7
Common name: forkhead box O4

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description: A member of the forkhead family, FOXO4 plays a role in development [802] and in insulin (INS) signalling. In roundworms, a homologue of FOXO4, daf-16, has been associated with ageing [628], and overexpression of another homologue, dFOXO, in adult fat body of fruit flies increased longevity in females [1238]. In mice targeting the interaction between FOXO4 and TP53 in senescent cells has been found to trigger apoptosis, demonstrating FOXO4 as a pivot in senescent cell viability. This targeted apoptosis restored fitness, fur density and renal function [4506]. FOXO4's role in human ageing has not yet been determined.

Cytogenetic information

Cytogenetic band: Xq13.1
Location: 71,096,149 bp to 71,103,534 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0006355; regulation of transcription, DNA-templated
GO:0006366; transcription from RNA polymerase II promoter
GO:0007050; cell cycle arrest
GO:0007095; mitotic G2 DNA damage checkpoint
GO:0007517; muscle organ development
GO:0007568; aging
GO:0008285; negative regulation of cell proliferation
GO:0008286; insulin receptor signaling pathway
GO:0014911; positive regulation of smooth muscle cell migration
GO:0016525; negative regulation of angiogenesis
GO:0031667; response to nutrient levels

And 7 more GO terms

Cellular component:

GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005829; cytosol

Function:

GO:0000981; RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003677; DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0005515; protein binding
GO:0008013; beta-catenin binding
GO:0008134; transcription factor binding
GO:0019899; enzyme binding
GO:0042802; identical protein binding
GO:0043565; sequence-specific DNA binding
GO:1990841; promoter-specific chromatin binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: AKT1, PIN1, CREBBP, FEN1, FOXO1, SIRT1, MDM2, ESR1, CTNNB1
STRING interaction network

Retrieve sequences for FOXO4

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: daf-16
Danio rerio: foxo4
Drosophila melanogaster: foxo
Mus musculus: Foxo4
Rattus norvegicus: Foxo4
Saccharomyces cerevisiae: HCM1
Schizosaccharomyces pombe: sep1

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as daf-16
A homolog of this gene for Drosophila melanogaster is present as foxo
A homolog of this gene for Saccharomyces cerevisiae is present as HCM1

GenDR gene manipulations

A homolog of this gene for Drosophila melanogaster is present as foxo
A homolog of this gene for Caenorhabditis elegans is present as daf-16

LongevityMap

This gene is present as FOXO4

CellAge

This gene is present as FOXO4