- Symbol
- Ire1
- Name
- Inositol-requiring enzyme-1
- Organism
- Drosophila melanogaster (AnAge)
- Observations
- Whole body depletion of Ire1 using RNA interference reduced the lifespan of flies and negated the lifespan extending effects of dietary restriction. This effect was found to be tissue specific, Ire1 expression in the midgut is required for starvation tolerance and lifespan extension.
- Lifespan Effect
- Decrease
- Genetic Manipulation
- RNA interference
- Longevity Category
- Pro-Longevity
- Primary reference
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- GenAge model organism genes
- A homolog of this gene for Caenorhabditis elegans is present as ire-1
- GenDR gene manipulations
- This gene is present as Ire1
- A homolog of this gene for Caenorhabditis elegans is present as ire-1
- A homolog of this gene for Saccharomyces cerevisiae is present as IRE1
- Caenorhabditis elegans
- ire-1
- Saccharomyces cerevisiae
- IRE1
- Schizosaccharomyces pombe
- ppk4
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- View on Entrez Gene database (42358)
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar
GenAge entry for Ire1 (Drosophila melanogaster)