Drosophila melanogaster GenDR Dietary Restriction Gene Manipulation: Ire1

Gene Information (Entrez Gene ID: 42358)

Symbol
Ire1
Aliases
CG4583 dire-1 dIRE1 Dmel\CG4583 Ire ire-1 Ire-1 IRE-like ire1 IRE1
Name
Inositol-requiring enzyme-1
Organism
Drosophila melanogaster (AnAge)
Entrez Gene ID
42358

Potential relevance to dietary restriction and ageing

Observations

Whole body depletion of Ire1 using RNA interference reduced lifespan in flies and negated the lifespan extending effects of dietary restriction. This effect was found to be tissue specific, Ire1 expression in the midgut is required for starvation tolerance and lifespan extension.

References

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as ire-1
    • This gene is present as Ire1
    GenDR gene manipulations
    • A homolog of this gene for Caenorhabditis elegans is present as ire-1
    • A homolog of this gene for Saccharomyces cerevisiae is present as IRE1

    Homologs

    Caenorhabditis elegans
    ire-1
    Saccharomyces cerevisiae
    IRE1
    Schizosaccharomyces pombe
    ppk4

    External links

    FlyBase
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    Ensembl
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    Entrez Gene
    ID 42358
    Homologues
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    UniProt
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    Internet
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