LongevityMap Gene
Gene details
- HGNC symbol
- WDR13
- Aliases
- MG21
- Common name
- WD repeat domain 13
- Description
- This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. A similar protein in mouse is thought to be a negative regulator of the pancreatic beta cell proliferation. Mice lacking this gene exhibit increased pancreatic islet mass and higher serum insulin levels, and are mildly obese. [provided by RefSeq, Nov 2016]
- Cytogenetic Location
- Xp11.23
- UCSC Genome Browser
- View Xp11.23 on the UCSC genome browser
- OMIM
- 300512
- Ensembl
- ENSG00000101940
- UniProt/Swiss-Prot
- WDR13_HUMAN
- Entrez Gene
- 64743
- UniGene
- 521973
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Italian (Northern) and Japanese
- Study Design
- AGTR1 was sequenced in 173 Italian centenarians (99-106 y, mean 100.9 ± 1.7 y, 83% female) and 376 younger controls (49-78 y, mean 65.9 ± 9.1 y, 43 % females). The results were then verified in 589 Japanese cases (99-115 y, mean 104.5 ± 3 y, 84% femal) and 422 controls (69-72 y, mean 70.1 ± 0.9 y, 52 % female).
- Conclusions
- rs422858, rs275653 were significantly associated with extreme longevity (P = 0.004). Other SNPs were not associated with longevity.
- Indentifier
- rs2272656
- Reference