LongevityMap Gene
Gene details
- HGNC symbol
- TERF2
- Aliases
- TRF2; TRBF2
- Common name
- telomeric repeat binding factor 2
- Description
- This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 16q22.1
- UCSC Genome Browser
- View 16q22.1 on the UCSC genome browser
- OMIM
- 602027
- Ensembl
- ENSG00000132604
- UniProt/Swiss-Prot
- TERF2_HUMAN
- Entrez Gene
- 7014
- UniGene
- 63335
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Terf2
- GenAge human genes
- This gene is present as TERF2
- CellAge
- This gene is present as TERF2
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
- Conclusions
- The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
- Indentifier
- rs9925619
- Reference