LongevityMap Gene
Gene details
- HGNC symbol
- RECQL5
- Aliases
- RECQ5
- Common name
- RecQ like helicase 5
- Description
- The protein encoded by this gene is a helicase that is important for genome stability. The encoded protein also prevents aberrant homologous recombination by displacing RAD51 from ssDNA. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
- Cytogenetic Location
- 17q25.1
- UCSC Genome Browser
- View 17q25.1 on the UCSC genome browser
- OMIM
- 603781
- Ensembl
- ENSG00000108469
- UniProt/Swiss-Prot
- A0A024R8M9_HUMAN
- Entrez Gene
- 9400
- UniGene
- 632229
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- rcq-5
- Danio rerio
- recql5
- Drosophila melanogaster
- RecQ5
- Mus musculus
- Recql5
- Rattus norvegicus
- Recql5
- Saccharomyces cerevisiae
- SGS1
In other databases
- GenAge model organism genes
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
- Conclusions
- The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
- Indentifier
- rs820157
- Reference