LongevityMap Gene
Gene details
- HGNC symbol
- RAD54L
- Aliases
- HR54; hHR54; RAD54A; hRAD54
- Common name
- RAD54 like (S. cerevisiae)
- Description
- The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity with Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. This protein has been shown to play a role in homologous recombination related repair of DNA double-strand breaks. The binding of this protein to double-strand DNA induces a DNA topological change, which is thought to facilitate homologous DNA paring, and stimulate DNA recombination. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Dec 2008]
- Cytogenetic Location
- 1p34.1
- UCSC Genome Browser
- View 1p34.1 on the UCSC genome browser
- OMIM
- 603615
- Ensembl
- ENSG00000085999
- UniProt/Swiss-Prot
- A8K996_HUMAN
- Entrez Gene
- 8438
- UniGene
- 642042
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- rad-54
- Danio rerio
- rad54l
- Drosophila melanogaster
- okr
- Mus musculus
- Rad54l
- Rattus norvegicus
- Rad54l
- Saccharomyces cerevisiae
- RAD54
- Schizosaccharomyces pombe
- rhp54
In other databases
- CellAge gene expression
- This gene is present as RAD54L
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
- Conclusions
- The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
- Indentifier
- rs9793263
- Reference