LongevityMap Gene
Gene details
- HGNC symbol
- RAD51
- Aliases
- RECA; BRCC5; FANCR; MRMV2; HRAD51; RAD51A; HsRad51; HsT16930
- Common name
- RAD51 recombinase
- Description
- The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
- Cytogenetic Location
- 15q15.1
- UCSC Genome Browser
- View 15q15.1 on the UCSC genome browser
- OMIM
- 179617
- Ensembl
- ENSG00000051180
- UniProt/Swiss-Prot
- RAD51_HUMAN
- Entrez Gene
- 5888
- UniGene
- 631709
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Danio rerio
- rad51
- Drosophila melanogaster
- spn-A
- Mus musculus
- Rad51
- Rattus norvegicus
- Rad51
- Saccharomyces cerevisiae
- RAD51
- Schizosaccharomyces pombe
- rhp51
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as RAD51
- GenAge human genes
- This gene is present as RAD51
- CellAge gene expression
- This gene is present as RAD51
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
- Conclusions
- The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
- Indentifier
- rs5030783
- Reference