LongevityMap Gene
Gene details
- HGNC symbol
- PPIH
- Aliases
- CYPH; CYP-20; USA-CYP; SnuCyp-20
- Common name
- peptidylprolyl isomerase H
- Description
- The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome. [provided by RefSeq, Jul 2008]
- Cytogenetic Location
- 1p34.2
- UCSC Genome Browser
- View 1p34.2 on the UCSC genome browser
- OMIM
- 606095
- Ensembl
- ENSG00000171960
- UniProt/Swiss-Prot
- PPIH_HUMAN
- Entrez Gene
- 10465
- UniGene
- 256639
- 1000 Genomes
- 1000 Genomes
Homologs in model organisms
- Caenorhabditis elegans
- cyn-11
- Danio rerio
- ppih
- Drosophila melanogaster
- CG17266
- Mus musculus
- Gm7879
- Rattus norvegicus
- Ppih
- Saccharomyces cerevisiae
- CPR2
- Saccharomyces cerevisiae
- CPR5
- Schizosaccharomyces pombe
- cyp3
In other databases
- CellAge gene expression
- This gene is present as PPIH
Studies (1)
Significant/Non-significant: 0/1
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
- Conclusions
- The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
- Indentifier
- rs7556150
- Reference